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An amino acid, C9H11NO4, that occurs widely in animals and plants. In humans and other mammals, it is formed in the liver from tyrosine and converted to dopamine in the brain.



(Biochemistry) See L-dopa


(ˈdoʊ pə)

an amino acid, C9H11NO4, formed from tyrosine in the liver during melanin and epinephrine biosynthesis. Compare L-dopa.
[< German Dopa (1917), contraction of 3, 4-Dioxyphenylanin]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.dopa - amino acid that is formed in the liver and converted into dopamine in the brain
amino acid, aminoalkanoic acid - organic compounds containing an amino group and a carboxylic acid group; "proteins are composed of various proportions of about 20 common amino acids"
Bendopa, Brocadopa, Larodopa, L-dopa, levodopa - the levorotatory form of dopa (trade names Bendopa and Brocadopa and Larodopa); as a drug it is used to treat Parkinson's disease
References in periodicals archive ?
The biochemical 3,4-dihydroxyphenylalanine (DOPA) acts in several aspects of insect biology including circadian rhythms, neurotransmission, tanning of cuticle, immunity, sclerotization, melanization, and wound repair in insects (Birman et al.
Hydroquinone (HQ), a phenolic compound, blocks the conversion of 3,4-dihydroxyphenylalanine (DOPA) to melanin through inhibiting tyrosinase7 and reduces dyschromia through melanocyte downregulation, prevention of melanosome production, and reduction of melanin transfer to keratinocytes.
Tyrosinase is the rate limiting enzyme of melanogenesis and the main target of antimelanogenesis [8] and catalyzes the oxidation of L-tyrosine to 3,4-dihydroxyphenylalanine (DOPA), which forms dopachrome.
Tyrosinase is rate-limiting enzyme controlling the production of melanin and catalyze the conversion of L-tyrosine supplied from the blood to 3,4-dihydroxyphenylalanine, then to dopaquinone.
It is involved in the biosynthesis of melanin and catalyses the ortho-hydroxylation of tyrosine (monophenol) to 3,4-dihydroxyphenylalanine or DOPA (o-diphenol) and the oxidation of DOPA to dopaquinone (o-quinone).
Fujita, "Tyrosinase-catalyzed binding of 3,4-dihydroxyphenylalanine with proteins through the sulfhydryl group," Biochimica et Biophysica Acta, vol.
These dopamine-deficient mice required daily administration of 3,4-dihydroxyphenylalanine (Ldopa) for survival beyond two to three weeks of age.
Aloe vera (Liliaceae) Gel Inhibit stimulated granulocyte MMPs Inhibit tyrosine hydroxylase and 3,4-dihydroxyphenylalanine oxidase 3.

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