HIV-positive pregnant women who are already stable on 3TC
, EFV and TDF should be switched to the FDC treatment
Drugs: Twenty tablets/capsules of NVP (Nevirex 200, Aurobindo Pharma Limited, India), 3TC
(Lamivox 150, Aurobindo Pharma Limited, India), d4T (Stavir 30, Cipla, India) each were analysed for their drug content by HPLC and spectrophotometric methods.
TDF with EFV and either 3TC
or FTC have been shown to have high and durable virological activity with good tolerability and minimal long-term toxicity with up to 3 years of follow-up [25,31].
4 log drop in viral load in the subset of patients who were not receiving 3TC
or FTC in their background treatment regimen versus a 0.
A planned 1-year pilot study of once-daily triple-nucleoside combination therapy with ABC, 3TC
, and TDF was also stopped early because of virologic failure in 12 of 36 patients--8 of whom never successfully decreased their viral load and 4 of whom had a rebound in viral load after an initial decrease, Dr.
In Cote d'Ivoire, HIV that was resistant to AZT was found in 43% of patients while 15% of patients were resistant to 3TC
Since Glaxo didn't invent or discover AZT, Ziagen or 3TC
, what could possibly justify the difference?
Laval, Canada; 514-978-7771) announced that the US District Court, Northern District of Georgia issued an order granting BioChem Pharma's motion to stay the patent infringement suit filed by Emory University (Atlanta, GA) against BioChem and Glaxo Wellcome (London, United Kingdom) involving 3TC
Is superior in antiviral activity to 3TC
in failing patients with the M184V mutation.
A major government clinical trial comparing three HIV treatments stopped the arm using abacavir plus AZT plus 3TC
(Trizivir[R]) alone, after patients in that arm " experienced virologic failure earlier and more frequently than patients who were randomized to receive either of the other two treatment regimens being evaluated in the study.
The study was designed to compare the efficacy and safety of a treatment regimen of Viread, lamivudine (3TC
) and efavirenz to a regimen of stavudine, 3TC
and efavirenz in 600 antiretroviral-naive patients with HIV infection.
Not only can't the state drug assistance program offer its 8,000 patients 3TC
, but its approved list doesn't include saquinavir, the first of a new, important class of drugs called protease inhibitors.