45,X karyotype - definition of 45,X karyotype by The Free Dictionary
Turner syndrome (redirected from 45,X karyotype)
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Tur·ner syndrome (tûr′nər) also Tur·ner's syndrome (-nərz)
A congenital condition of girls and women caused by complete or partial absence or deficiency of one X chromosome, characterized by short stature, a webbed neck, low-set ears, skeletal abnormalities, and infertility owing to ovarian failure.
[After Henry Hubert Turner (1892-1970), American endocrinologist.]
References in periodicals archive
The structurally defective chromosomes are believed to be fetoprotective, compared to the 45,X karyotype
that explains the higher ratio of 46,X,i(X)(q10) and 46,X/r(X) fetuses who are diagnosed as pregnancy advances to term .
This leads to the hypothesis that those fetuses with the 45,X karyotype
who survive to term represent an "elite" with a critical mass of 46,XX cells necessary for survival.
G-banding with trypsin treatment and Giemsa stain (GTG-banded) chromosome analysis showed a mosaic karyotype with two cell lines: five cells with a 45,X karyotype
and 15 cells with a 46,XY karyotype.