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A salicylate drug derived from sulfasalazine, C7H7NO3, used primarily to treat inflammatory bowel disease.



(USAN), mesalazine (INN) n mesalamina, mesalazina (INN)
References in periodicals archive ?
For example, corticosteroids were confirmed to be associated with both hypocoagulation and hypercoagulation changes,[15] and 5-aminosalicylic acid significantly reduced both spontaneous and thrombin-induced PLT activation.
Comparative absorption of 5-aminosalicylic acid (5-ASA) after administration of a 5-ASA enema and salazosulfapyridine (SASP) after an SASP suppository in Japanese volunteers.
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis.
3) Hence, 5-aminosalicylic acid (5-ASA) was given as standard treatment to compare the efficacy of the test drug.
Oral 5-aminosalicylic acid (5-ASA; 3600 mg daily) was initiated, and his prednisone dose was increased (60 mg daily).
A standard therapy is the administration of 5-aminosalicylic acid (a nonsteroidal anti-inflammatory drug), which reduces (via cyclooxygenase-2 (Cox-2)) the formation of leukotrienes and prostaglandins, focussing on blocking inflammatory processes, that is, their mediators [8].
Ever green" large volume API such as acetylsalicylic acid, ibuprofen, paracetamol or 5-aminosalicylic acid produced at the thousand of ton scale are characterized by very long life cycles while commanding prices rarely exceeding $20-25 Kg and most often produced in dedicated highly automated units.
Twenty patients with mild-to-moderate ulcerative colitis who had failed to respond adequately to 5-aminosalicylic acid and/or azathioprine were randomly assigned in a 4:1 ratio to receive, in double-blind fashion, adjunctive treatment with Polyphenon E (a green tea extract) or placebo for 8 weeks.
Documented cases of TIN in CD have mostly been reported in patients treated with 5-aminosalicylic acid (5-ASA), the nephrotoxicity of which has been described previously.
5-Aminosalicylic acid reverses endosulfan-induced testicular toxicity in male rats.
Another approach for increasing blood 6-TGN concentrations is the combination of 5-aminosalicylic acid (5-ASA) and thiopurine.
He had a diagnosis of ulcerative colitis and was treated with 5-aminosalicylic acid (5-ASA or mesalazine) 500 mg, six times a day (3g/day) for six years, with minimal or no improvement.
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