fluorouracil

(redirected from 5-FU)
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fluor·o·u·ra·cil

 (flo͝or′ō-yo͝or′ə-sĭl, flôr′-)
n.
An antineoplastic agent, C4H3FN2O2, used especially in the treatment of cancers of the skin, breast, and digestive system.

fluorouracil

(ˌflʊərəʊˈjʊərəsɪl)
n
a chemotherapy drug used in the treatment of cancer, which operates by interfering with the abnormal growth of cells

fluor•o•u•ra•cil

(ˌflʊər əˈyʊər ə sɪl, ˌflɔr-, ˌfloʊr-)

n.
a pyrimidine analog, C4H3FN2O2, used in the treatment of certain cancers.
[1955–60]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.fluorouracil - an antimetabolite used to treat certain cancers
antimetabolite - an antineoplastic drug that inhibits the utilization of a metabolite
Translations

fluorouracil

n fluorouracilo
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References in periodicals archive ?
In a randomized trial involving 131 patients, applying topical 5% 5-FU cream plus 0.005% calcipotriol ointment twice daily for 4 days significantly reduced the number of actinic keratoses (mean reduction, 88% vs 26% for Vaseline[R]; P<0.0001).
The trial is a single-arm open-label Phase 1/2a trial assessing the safety, pharmacokinetics and efficacy of repeated and ascending doses of the product administered by IHA route in combination with oral 5-FC, a non-cytotoxic pro-drug that can be converted in 5-FU. The study is likely to commence in the fourth quarter of 2019 and is to enrol up to 75 patients.
Oral mucositis was induced by two intraperitoneal (ip) injections on the first and second experimental days, using 60 and 40 mg/kg of 5-FU, respectively.
In the current study, we examined MEs from three different tree species (ash, oak and apple) for their potential to induce cell death in normal (IEC-6) and transformed (Caco-2) colonic epithelial cells and whether the three extracts differentially had an impact on 5-FU induced toxicity.
Conclusion: Intralesional 5-FU is an effective and safe treatment for treatment of common, plantar and genital warts.
5-fluorourasil (5-FU) was used as positive control and distributed with various concentrations 0-625 mg/mL (Davoodi et al., 2013) and fucoxanthin standard (Sigma) as marker substance of brown seaweeds with various concentrations 0 - 150 mg/mL.
The patient was treated with provisional diagnosis of LV dysfunction secondary to chemotherapy (5-FU).
muricata leaves were purchased from a local supermarket; silver nitrate (AgN[O.sub.3]) and 5-FU were obtained from Sigma-Aldrich; serological pipettes (5, 10, and 25 mL) and 50 mL centrifuge tubes were purchased from Santa Cruz Biotechnology, Inc.; 25 [cm.sup.3] cell-culture flask were purchased from Corning[R]; and 48-well cell-culture cluster were purchased from Costar[R]."
Some animal studies also demonstrated the effectiveness of BVZ combined with 5-Fu (BVZ + 5-Fu) in preventing scarring after GFS [24].
The adsorption process of the 5-fluorouracil (5-Fu) molecule to 1a was investigated using grand canonical Monte Carlo (GCMC) simulations at 300 K.
The histological and clinical similarity of urachal to colonic adenocarcinoma suggests that regimens that include 5-FU may be effective [14].