NUC-3373 is NuCana's second ProTide in clinical development and is a transformation of the active anti-cancer metabolite of 5-fluorouracil
, one of the most widely prescribed anti-cancer agents.
Leucovorin Calcium is also used as a rescue drug after high-dose methotrexate therapy in osteosarcoma, in the treatment of megaloblastic anemia due to folic acid deficiency when oral therapy is not feasible, and in combination with 5-fluorouracil
to prolong survival in the palliative treatment of patients with advanced colorectal cancer.
Conclusion: Trimodality treatment with TURBT, chemotherapy and chemo-radiation is a feasible option for bladder preservation in muscle invasive bladder cancer patients with compromised renal functions if we use 5-fluorouracil
and mitomycin chemotherapy.
Pain related to treatment, side effects and cost can be determining factors in choosing a therapy.9 5-Fluorouracil
(FU) is an antimetabolite that suppresses cell division and causes cell cycle arrest.10 Topical 5-FU is used in the treatment of warts but is not very effective.11 Intralesional injection of 5-FU permits higher drug concentrations throughout the lesion and previous study has shown it effectiveness in treatment of warts.12
For cryotherapy, curettage and cryotherapy, 5-fluorouracil
, imiquimod, and photodynamic therapy using methyl-aminolevulinic acid or aminolevulinic acid, the recurrence rates were higher (22.3, 19.9, 18.8, 14.1, 18.8, and 16.6 percent, respectively).
The company hopes to establish its efficacy as a treatment for patients with advanced gastric cancer who have progressed after first-line standard chemotherapy with 5-fluorouracil
(5-FU) and platinum doublets.
-- A standard course of topical 5-fluorouracil
(5-FU) does not noticeably improve visual signs of facial photoaging, such as forehead lines and crow's feet, according to the results of a blinded, controlled study of 281 elderly white men.
Saikawa et al., "Thymidylate synthetase (TS) genotype and TS/dihydropyrimidine dehydrogenase mRNA level as an indicator in determining chemosensitivity to 5-fluorouracil
in advanced gastric carcinoma," Anticancer Research, vol.
based chemotherapeutic regimens are extremely potent in treating several cancers including high grade colorectal malignancies.
S-1 is an oral anticancer agent containing tegafur, a prodrug of 5-fluorouracil
(5-FU), and two modulators.
Objective: To compare the mean change in corneal astigmatism and clinical appearance after intralesional injection of 5-Fluorouracil
in primary and recurrent pterygia.
Objective: To determine mean change in visual acuity, corneal astigmatism and clinical appearance of pterygium after intralesional injection of 5-Fluorouracil