In order to investigate the inhibition type and inhibition constant ([K.sub.i]) values of extracts, Lineweaver-Burk and Dixon plots were used against a-glucosidase
Acarbose tablet, one of the major compounds of a-Glucosidase
inhibitors with limited competitors in China, is the Group's key R and D project in the second half of 2018.
cilicica was also found to modulate the action of other enzymes namely a-amylase and a-glucosidase
, which are the main targets of glycaemic control.
An effective suggestion for type 2 diabetes management is the inhibition of a-glucosidase
and a-amylase .
Sample treatments include a-glucosidase
inhibitors (AGIs; acarbose, miglitol and voglibose) to reduce the absorption of carbohydrates in the intestine and control postprandial hyperglycemia.
The first large-scale Pompe disease newborn screening pilot study was carried out at the National Taiwan University Hospital (covering about one-third of the newborns in Taiwan) using a multitier assay to measure 3 enzymatic activities: (a) GAA, measured at low pH in the presence of acarbose; (b) neutral a-glucosidase
, measured at increased pH in the absence of acarbose; and (c) total a-glucosidase
, measured at low pH in the absence of acarbose (4, 6).
Therefore, the possible way for reduction of the rate of carbohydrate digestion and hence decrease of the after-meal glucose levels is an inhibition of the activity of a-glucosidase
Table 2: Inhibitory effect of a-glucosidase
activity of Nopal dry powder (NPDP) and water extract (NPWE).
sakazakii appears to constitutively express high levels of a-glucosidase
. This enzyme hydrolyses the chromogenic substrate 5-bromo-4chloro-3-indolyl-a-D-glucopyranoside present in the medium, producing green to blue-green coloured colonies.
(17) Thus, long-term prophylaxis with this a-glucosidase
inhibitor in high-risk individuals with impaired glucose tolerance could provide a pharmacological option, along with lifestyle modification, to help reduce the burden of type 2 diabetes.
inhibitors for patients with type 2 diabetes mellitus: results from a Cochrane systematic review and meta-analysis.
A previous report also described the role of lactose as inducer for endoglucanase and A-glucosidase
(Seiboth et al.