A recent meta--analysis (9) focused on adipokine profiles (ADIPOQ
, LEP and RETN) as biomarkers in the gingival crevicular fluid (GCF) of obese and non-obese CP patients.
Indeed, these rats showed altered WAT (parametrial tissue-pad) functionality, such as enlarged pad mass, replete of large (insulin-resistant) adipocytes and containing very low ADIPOQ
To validate the results of differentially expressed genes in transcriptome sequencing, leptin (Lep), ghrelin (Ghr), insulin-like growth factor 1 (Igf1), and adinopectin (Adipoq
) genes were selected because they were differentially expressed in each diet group.
A selected gene panel from the genes identified by microarray analysis data based on their involvement in adipogenesis-related processes, including AdipoQ
, AP2, PPAR[gamma]2, CEBP[alpha], CNTFR, LPL, LIPE, ACACB, and PCK1, was chosen for validation using qRT-PCR (Figure 2(c)).
DIO2 expression was inversely related to the anti-inflammatory genes ADIPOQ
and PPARgamma in both VAT and SAT, but of the proinflammatory genes, only PAI-1 had a significant relationship to DIO2 expression.
Pode ser denominada de Acrp-30 (30-K Da adipocyte complementrelated protein), apM1 e adipoQ
, considerando que fora, simultaneamente, identificada por diferentes grupos (Kershaw e colaboradores, 2004; Fosenca-Alaniz e colaboradores, 2006; Ahima, 2006; Kadowaki e colaboradores, 2006; Pinto, 2014).
gene polymorphisms and susceptibility to polycystic ovary syndrome: a HuGE survey and meta-analysis.
Peralta-Romero JDJ, Karam-Araujo R, Burguete-Garcia AI, Estrada-Velasco BI, Lopez-Islas C, Figueroa-Arredondo PMDC, Valladares-Salgado A, Cruz M (2015) ADIPOQ
and ADIPOR2 gene polymorphisms: association with overweight/obesity in Mexican children.
is a novel adipose-specific gene dysregulated in obesity," The Journal of Biological Chemistry, vol.
In addition, recent study reported that progestin and adipoQ
receptors 3 (PAQR3), as a novel anchoring protein of SCAP/SREBP complex, also can regulate cholesterol biosynthesis and SREBP activation .
Using HExpoCHem, PCB 126 was associated, though not statistically significantly, with insulin sensitivity via a protein complex of ADIPOQ
(p > 0.05), and with arterial hypertension via a protein complex of AGTR1 and another complex of NOS3 (both p > 0.05).
In another study, the same team of researchers found that centenarians and their offspring also had present a genetic variant of the ADIPOQ
gene, which expresses higher amounts of the hormone adiponectin.