A study showed a somatic activating mutation of the AKT1
oncogene kinase, an enzyme involved in cell proliferation, in this disorder .
Three Akt isoforms are known, namely, Akt1
, Akt2, and Akt3.
Schroeder, "The potassium transporter AtHAK5 functions in [K.sup.+] deprivation-induced high-affinity [K.sup.+] uptake and AKT1
[K.sup.+] channel contribution to [K.sup.+] uptake kinetics in Arabidopsis roots," Plant Physiology, vol.
Yang et al., "FOXO3 induces FOXO1-dependent autophagy by activating the AKT1
signaling pathway," Autophagy, vol.
Petersen, "Inhibition of hydrogen peroxide signaling by 4-hydroxynonenal due to differential regulation of Akt1
and Akt2 contributes to decreases in cell survival and proliferation in hepatocellular carcinoma cells," Free Radical Biology and Medicine, vol.
Blots were exposed to anti-GSK3 (Millipore), anti-phosphotyrosine GSK3 (Millipore), anti-phospho-ERK1/2 (Thr202/Tyr204) (Millipore), anti-[alpha]-tubulin, and anti-beta-catenin (Millipore) and recognized by an HRP-conjugated horse anti-mouse secondary antibody (Santa Cruz Inc); antibodies to detect phospho-AKT1/2/3 (Ser473), total Akt1
, hnRNPA1, and Anxa7 (Santa cruz Inc) SF2/ASF1 (Santa Cruz Inc) were recognized by an HRP-conjugated goat anti-rabbit secondary antibody (Santa Cruz Inc.).
Varios factores intracelulares han sido implicados en la promocion e inhibicion de autofagia: multiples oncogenes (en particular fosfatidilinositol 3-kinasa, PI3K; Akt1
activada; proteinas antiapoptotica de la familia Bcl2) inhiben la autofagia.
, AKT2, E2F1, IKK and NF-[kappa]B1) exhibited down-regulation.
A potassium channel, OsAKT1, homologous to the Arabidopsis root inward rectifier AKT1
Triciribine (API2) is a tricyclic nucleoside analogue that inhibits AKT1
, -2, and -3 by interfering with membrane integration, which has been shown to inhibit AKT in vivo [12,13].
Trapman, "E17K substitution in AKT1
in prostate cancer," British Journal of Cancer, vol.
Association of polymorphisms in AKT1
and EGFR with clinical outcome and toxicity in non-small cell lung cancer patients treated with gefitinib.