eld

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Related to ARID1A: ARID1B

eld

(ɛld) or

eild

n
1. old age
2. olden days; antiquity
[Old English eldu; related to Old Norse elli; see old]

eld

(ɛld)

n. Archaic.
1. age.
2. old age.
3. olden times; antiquity.
[before 1000; Middle English elde, Old English eldo, ieldo, derivative of (e)ald old; compare world]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.eld - a late time of lifeeld - a late time of life; "old age is not for sissies"; "he's showing his years"; "age hasn't slowed him down at all"; "a beard white with eld"; "on the brink of geezerhood"
time of life - a period of time during which a person is normally in a particular life state
mid-sixties, sixties - the time of life between 60 and 70
mid-seventies, seventies - the time of life between 70 and 80
mid-eighties, eighties - the time of life between 80 and 90
mid-nineties, nineties - the time of life between 90 and 100
dotage, second childhood, senility - mental infirmity as a consequence of old age; sometimes shown by foolish infatuations
2.eld - a time of life (usually defined in years) at which some particular qualification or power ariseseld - a time of life (usually defined in years) at which some particular qualification or power arises; "she was now of school age"; "tall for his eld"
lifespan, lifetime, life-time, life - the period during which something is functional (as between birth and death); "the battery had a short life"; "he lived a long and happy life"
time of life - a period of time during which a person is normally in a particular life state
age of consent - the minimum age for marrying without parental consent or the minimum age for consensual sexual relations; intercourse at an earlier age can result in a charge of assault or statutory rape; the age differs in different states of the Union
legal age, majority - the age at which persons are considered competent to manage their own affairs
nonage, minority - any age prior to the legal age
drinking age - the age at which is legal for a person to buy alcoholic beverages
voting age - the age at which a person is old enough to vote in public elections
References in periodicals archive ?
ENPNewswire-August 20, 2019--Johns Hopkins University - Laboratory Studies Identify A Potential Way to Treat Human Cancers with ARID1A Mutations
The pathogenesis of ovarian cancer is closely related to ARID1A (AT-rich interactive domain-containing protein 1A), which is present in up to 57% of patients (2) and acts as a tumor suppressor in various cancers (3).
It has been shown that mutations of ARID1A gene contribute to carcinogenesis, and cause transformation of cells in association with the PI3K/AKT pathway (8- 12).
Based on figure 2, PAX5 transcription factor and genes including ARID1A, CDC42 and LPPR4 were highlighted as the most important units within the genes network with more interconnected links (Figure 2).
Endometrioid carcinomas of the ovary and endometrium are both described to contain PTEN, PIK3CA, ARID1A, PPP2R1A, and CTNNB1 (9-catenin) mutations.
AT-rich interactive domain 1A (ARID1A) is a tumor suppressor gene in a variety of human cancers.
Chromatin remodeling genes, such as EED, ARID1A, ING5, CTBP1, CBX3, CBX7, MTA1, and NSD1, have key roles in the carcinogenesis of GC (10, 11, 13-16).
Genomic alterations by next-generation sequencing (Foundation One) on the liver biopsy revealed CCND1 amplification, ESR1 Y537S mutation, ARID1A L1915fs*3 mutation, stable microsatellites, and an intermediate tumor burden (six mutations/Mb).
These unusual versions of the protein are associated with adult liver cancer cells with mutations in tumour-suppressor genes called TP53 and ARID1A.
For example, ARID1A, identified as a tumor suppressor gene, encodes BAF250a, a key component of the SWI-SNF chromatin remodeling complex.
Similarly, ARID1A, another subunit of SWI/SNF, acts as tumor suppressor in colon cancer and its loss is solely able to activate an oncogenic transcriptional program and promote invasive colon adenocarcinomas in mouse [96].
Considering the lack of salvage therapies available in this scenario, a FoundationOne[R]Heme genomic profiling assay was requested, which revealed 5 nondrugable genomic alterations: ATM Q2593* mutation, ARID1A S2149fs*47 mutation, CDKN2A/B loss, EP300 L415P mutation (subclonal), and MLL3 Y306* mutation.