ACU193 is a fully humanized IgG2 monoclonal antibody that selectively binds soluble Abeta
oligomers, potentially blocking their toxic effects.
BAN2401 selectively binds to neutralize and eliminate soluble, toxic Abeta
aggregates that are thought to contribute to the neurodegenerative process in Alzheimer's disease.
Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic abeta
in transgenic APP/PS1 hippocampus.
Summary: Looking to mix physical and digital spaces, Google has released abeta
SDK for augmented reality, dubbed ARCore, that is focused …
Diabetes mellitus accelerates Abeta
pathology in brain accompanied by enhanced GAbeta generation in nonhuman primates.
2010) Mechanism of amyloid plaque formation suggests an intracellular basis of Abeta
IL-10 and glucocorticoids inhibit Abeta
(1-42)- and lipopolysaccharide-induced pro-inflammatory cytokine and chemokine induction in the central nervous system.
The findings of the study showed that antioxidant disparity results increasing susceptibility of Gpxl--/-- cells to Abeta
These insights highlight crenezumab's unique mechanism of action, particularly regarding Abeta
oligomers, and provide a strong rationale for the evaluation of crenezumab as a potential AD therapy.
Crenezumab is a fully humanised IgG4 monoclonal antibody that binds all forms of misfolded Abeta
proteins to prevent and break up their aggregation and promote their disaggregation.
Absence of synaptophysin near cortical neurons containing oligomer Abeta
in Alzheimer's disease brain.
Gate control uses counter-stimulation of aBeta
motion nerves and C-fiber cold nerves to overwhelm the aDelta pain fibers.