Out of these 40 cases, which underwent surgical excision followed by histologic evaluation, 16 cases were of pleomorphic adenoma, 6 cases of chronic sialadenitis, 2 cases of Warthin's tumour, 3 cases of parotitis, 4 cases of mucoepidermoid carcinoma, 4 cases of acinic cell carcinoma
, 5 cases of adenoid cystic carcinoma were reported.
Because of the prominent oncocytic morphology masking the epidermoid phenotype, the oncocytic variant of MEC, in particular, can pose a challenging differential diagnosis with WT, oncocytic cystadenoma, and acinic cell carcinoma
Out of 78 malignant Lacrimal gland tumours, 35 (9M, 26F) were Adenoid cystic carcinoma presenting in ages 14 to 75 years (Mean Age=31y), 25 (10M, 15F) were Adenocarcinoma with age range 4 to 72 years (Mean Age=40y), 15 were Lacrimal gland lymphoma (6M, 9F) with age range of 20 to 65 years (Mean Age=49y), 2 cases (2M) were of Acinic cell carcinoma
Type of malignant tumor were; mucoepidermoid carcinoma, adenoid cystic carcinoma, acinic cell carcinoma
, malignant mixed tumor and large duct adenocarcinoma.
Differential diagnosis: Includes acinic cell carcinoma
, mucoepidermoid carcinoma, and low-grade cribriform cystadenocarcinoma of the salivary gland.
PLAG1 upregulation can also be assessed by immunohistochemistry; most PAs (94%) are strongly immunoreactive for PLAG1,  whereas PLAG1 is negative in most SG carcinomas, including AdCC, MEC, and acinic cell carcinoma
3% of malignant tumors, followed by mucoepidermoid carcinoma and acinic cell carcinoma
09%) of salivary duct carcinoma and acinic cell carcinoma
all located in the parotid gland and seen in patients older than 45 years of age.
DISTRIBUTION AND TYPE OF SALIVARY GLAND TUMOURS Parotid Submandibular gland gland Malignant tumours Mucoepidermoid carcinoma 11 Adenoid cystic carcinoma 3 2 Acinic cell carcinoma
4 Malignant pleomorphic tumour 1 Epithelial-myoepithelial carcinoma 1 Squamous cell carcinoma 1 1 Adenocarcinoma 1 Carcinoma, undifferentiated 1 Lymphoma 1 Subtotal 24 (24.
33%] 0 Pleomorphic Adenoma Acinic Cell Carcinoma
0 1 [50.
In the past investigators have noticed histologic similarities between secretory carcinoma of the breast and acinic cell carcinoma
(AcCC) of both salivary gland and mammary origin, (1,2) and in 2008 it was found that AcCC of the breast lacked the ETV6 gene rearrangement found in secretory carcinoma of the breast.
Acinic cell carcinoma
accounts for approximately 2 to 6% of all salivary gland tumors.