somatic mutation

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Related to Acquired Mutation: somatic mutation, conditional mutant

somatic mutation

n
(Botany) a mutation occurring in a somatic cell, resulting in a change in the morphology or some other aspect of one part of an organism (usually a plant). It may be maintained by vegetative propagation but not by sexual reproduction
Translations
mutation somatique
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References in periodicals archive ?
GATA2 mutation can be seen in sporadic AML with normal cytogenetics and biallelic CEBPA mutations, in which the GATA2 mutation is considered as an acquired mutation. (54,55) More recently, GATA2 mutation has been identified as one of the germline mutations that confer predisposition to myeloid neoplasm.
Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders.
The acquired mutation in PNH is in the PIGA gene and originates in hematopoietic stem cells.
For example, T790M, an acquired mutation that renders NSCLC patients resistant to gefitinib or erlotinib, is found in approximately 50% of tumors from patients who have acquired resistance to these kinase inhibitors (1-4).
An acquired mutation in that rare cell or its descendants leads to clonal patches of many identical cells.
Thus, S-LAM develops from 2 acquired mutations (predominantly in TSC2), and patients with TSC-associated LAM have one germline mutation and one acquired mutation (again, predominantly in TSC2).
Acquired mutations in the GATA-1 gene have been found in blast cells in DS with myeloid leukemia [15].
While the vaccine was based on an early reference strain of A(H1N1) pdm09, the virus itself later acquired mutations in the hemagglutinin gene, leading to the emergence of new genetic clades, including 6B, which dominated in the 2013-2014 influenza season, and 6B.1, which dominated in 2015-2016.
PBMC-derived samples had more mutations in domain IIId than in plasma-derived IRESes suggesting a possible reduction in IRES activity by the acquired mutations in domain IIId in PBMCs.
Acquired mutations in ASXL1 in acute myeloid leukemia: prevalence and prognostic value.

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