Inhibition of MSTN and activin A
activities by affinitypurified ActRIIB-2a was compared with that of soluble ActRIIB-1 using the CAGA-luciferase assay in A204 cells.
Researchers from the Center on Aging found that human senescent fat cells release a protein called activin A
that impairs the function of fat tissue and their stem cells.
1- hiPSCs were incubated for 3 days with RPMI-1640 medium (Gibco, USA) containing 100 ng/ml Activin A
(R&D, USA) and FBS (Gibco, USA).
Therefore, we considered activin A
as a positional candidate affecting litter size and evaluated their sequence for potential causative genetic variation.
Thus, although activin A
and FSH exert a positive effect on the expression of receptors for FSH and inhibin-[beta]A subunit, respectively, there was not a significant increase in the rate of growth of secondary follicles cultured in vitro in the presence of both FSH and activin-A.
Several studies have shown that blocking the myostatin pathway can promote muscle growth, said Han, and some have shown that a molecule closely related to myostatin, called activin A
, becomes more abundant in patients with some cancers.
The two poster presentations describe the potential role of activin A
as an adverse biomarker for patients with metastatic breast cancer and of BMP9 as a biomarker for the identification and selection of patients with head and neck cancer.
The brain produces several factors after different types of injuries (3), and production of activin A
has been observed both in vitro and in vivo (4).
An early increase in activin A
has been found in newborns with perinatal hypoxia (5) and intraventricular hemorrhage (IVH) (6) and in infants developing HIE (7).
In the published studies, GRNOPC1 was found to produce numerous neurotrophic factors, including transforming growth factor [eth]1 (TGF-[eth]1), transforming growth factor [eth]2 (TGF-[eth]2), activin A
, midkine, vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF).
is a glycoprotein composed of 2 [beta]A subunits that belong to the transforming growth factor-[beta] superfamily of differentiation factors and is expressed in the central nervous system (8).
Because activin A
is a growth factor produced in the central nervous system (CNS) (5, 6), mainly after brain injury to modulate neuronal survival against toxicity (7-14), in the present study we investigated whether its concentrations in cerebrospinal fluid (CSF) collected from asphyxiated full-term newborns were higher in those developing HIE and whether this measurement could be useful for the early detection of postasphyxia HIE.