The researchers focused on the relationship between PKA and adenylyl cyclase
(AC), an enzyme involved in cyclic AMP (cAMP) production, a cellular messenger with a critical role in vascular cell function.
PSI researchers have now been able to depict the effector protein in this case adenylyl cyclase
and have produced the most detailed image to date of this type of membrane protein.
Its role is reflected in the dopamine binding and inhibiting the activity of adenylyl cyclase
, an enzyme from the lyase group which is a part of the cyclic adenosine monophosphate (cAMP) signal pathway which, in addition to the phosphatidylinositol pathway, represents the way in which the G-protein coupled receptors transmit a signal.
Adr is a catecholamine that interacts with hepatic AR and signals by coupling to the stimulatory G-protein G[alpha] leading to activation of adenylyl cyclase
and inducing glycogen breakdown and glucose release through cAMP-dependent pathway (12,13).
Dopamine +D1 [left & right arrow] Stimulates Adenylyl Cyclase
Vallar, "GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase
in human pituitary tumours," Nature, vol.
The company said the RT-100 AC6 gene transfer involves infusing an inactivated adenovirus vector encoding human adenylyl cyclase
type 6 (Ad5.hAC6) into the arteries that feed the heart during cardiac catheterization, a commonly performed procedure.
Experiments were conducted to investigate if the adenylyl cyclase
pathway is involved in the activation of IL-6 transcription profile in skeletal muscle cells.
Classically, LTP can be triggered by electrical high-frequency stimulation (HFS) and chemically induced by the adenylyl cyclase
activator forskolin [15,16].
The production of prostaglandin endoperoxides from arachadonic acid in the endothelium, specifically PGI2, stimulates adenylyl cyclase
to convert adenosine triphosphate (ATP) to cyclic adenosine monophosphate (cAMP), which also facilitates pulmonary vasodilatation.
IP is a b1 and b2-adrenomimetic drug and is used to relax the uterus, facilitate foetal mutations and exteriorise the uterus during CS.7,8 Its smooth muscle-relaxing action is brought about through the increase in myometrial cyclic adenosine monophosphate (cAMP) due to the activation of adenylyl cyclase
by the stimulation of b2 receptors, leading to a decrease in uterus contractions.9,10
(91) Considering that [G.sub.s] stimulates adenylyl cyclase
(AC) for the synthesis of cAMP, adaptive response of receptors coupled to [G.sub.s] opposes "downstream" stimulation of cAMP/PKA pathway induced by antidepressant drugs.