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His previous industry experience includes clinical drug development at GlaxoSmithKline, where he made significant contributions to several clinical development programs, including the currently marketed anti-viral pharmaceuticals, Ziagen, Trizivir and Agenerase.
Protease inhibitors (Pls) Amprenavir (APV, High-fat diet decreases Can be taken without Agenerase) 1 200 absorption and regard to meals but mg bid po decreases AUC.
Vertex said it sold the royalty stream from Lexiva and Agenerase, which it licensed to Glaxo, to strengthen its financial position and invest in other programs, particularly its hepatitis C drug programs.
Table 1 Common Antiretroviral Drugs (14-16) Classification Generic Name Trade Name Nucleoside reverse Abacavir sulfate Ziagen transcriptase inhibitors Abacavir sulfate + Trizivir (NRTI) lamivudine + zidovudine Didanosine (ddl) Videx, Videx EC Lamivudine (3TC) Epivir Lamiudine + zidovudine Combivir Stavudine (d4T) Zerit Tenofovir disoproxil Viread fumarate Zalcitabine (ddC) Hivid Zidovudine (AZT, ZDV) Retrovir Non-nucleoside reverse Delavirdine mesylate Rescriptor transcriptase inhibitors Efavirenz Sustiva (NNRTI) Nevirapine Viramune Protease inhibitors (PI) Amprenavir Agenerase Indinavir sulfate Crixivan Lopinavir + ritonavir Kaletra Nelfinavir Viracept Ritonavir Norvir Saquinavir Fortovase Saquinavir mesylate Invirase Fusion inhibitors (FI) Enfuvirtide Fuzeon
Alka-Seltzer, Maalox, Tums, and Rolaids can interfere with the stomach's absorption of Agenerase, Crixivan, Rescriptor, and Reyataz, while Axid, Pepcid, Tagamet, and Zantac should be entirely avoided by those taking Crixivan, Rescriptor, and Reyataz.
Fosamprenavir is a prodrug of amprenavir (Agenerase), and is converted into amprenavir in the body.
Other well-documented cutaneous reactions to antiretroviral drugs include pigmentary abnormalities triggered by zidovudine (Retrovir), a hypersensitivity reaction to abacavir (Ziagen), an exanthem brought on by amprenavir (Agenerase) and efavirenz (Sustiva), and Stevens-Johnson syndrome caused by nevirapine (Viramune).
It is a "pro-drug" of Agenerase (amprenavir), another protease inhibitor.
Lexiva is converted into amprenavir (Agenerase), a previously approved protease inhibitor, in the body.
Such new medications as Avandia for Type 2 diabetes, Ziagen and Agenerase AIDS treatments, and Seretide for asthma should also augment volume and help offset erosion in sales of such off-patent drugs as Zantac, an antiulcer agent; Ventolin, an asthma treatment; and Zovirax, for herpes.
Agenerase is used alongside other anti-viral drugs and is already available in America, Ghana, and Israel, where it has notched up sales of pounds 25million in the first half of the year.
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