The settlement alleges that the company misrepresented its antiplatelet drug, Aggrenox
, that was effective for many conditions 'below the neck,' such as heart attacks and congestive heart failure, and that it was superior to Plavix, without evidence to substantiate that claim; misrepresented that Micardis protected patients from early morning strokes and heart attacks and treated metabolic syndrome; misrepresented that Combivent could be used as a first-line treatment for bronchospasms associated with chronic obstructive pulmonary disease (COPD); Falsely stated that Atrovent and Combivent could be used at doses that exceeded the maximum dosage recommendation in the product labelling and that the drugs were essential for treatment of COPD.
The settlement made between all 50 states and the District of Columbia solves allegations that BIPI engaged in unfair, deceptive, or misleading practices in its promotion of Micardis, Aggrenox
, Atrovent, and Combivent by allegedly representing that the prescription drugs had sponsorship, approval, characteristics, ingredients, uses, benefits, quantities, or qualities that they did not have.
TABLE 1--Oral Anticoagulant/Antiplatelet Agents available in the United States Agent Class Name Available dosage PLATELET Ticlid (ticlopidine) 250mg tablet AGGREGATION INHIBITORS Pletal (cilostazole) 50mg, 100mg tablet Trental (pentoxifylline) 400mg tablet Plavix (dopidogrel) 75mg Effient (prasugrel) 5mg, 10mg Brilinta (ticagrelor) 90mg Persantine (dipyridamole) 25mg, 50mg, 75mg Aspirin 81 mg, 325mg Aggrenox
25mg-200mg (aspirin/dipyridamole) ANTICOAGULANT Coumadin (warfarin, 1 mg, 2mg, 2.
Otro caso es el del Aggrenox
, recetado para pacientes con derrames y trombosis, que la alemana Boehringer Ingelheim logro retardar hasta 2015.
Other antiplatelet drugs include clopidogrel (Plavix), ticlopidine (Ticlid), dipyridamole (Persantine) and Aggrenox
, a combination of dipyridamole and aspirin.
The DOJ announced yesterday that Boehringer will pay $95 million to resolve the allegations that it improperly promoted its anti-stroke drug Aggrenox
, its chronic obstructive pulmonary disease drugs Atrovent and Combivent, and its hypertension drug Micardis.
The study also showed that Boehringer's blood thinner Aggrenox
combined with aspirin was no better than a top-selling competitor, Plavix, in preventing stroke recurrence.
4 mg, Mirapex (pramipexole dihydrochloride) tablets, Aggrenox
(aspirin/extended-release dipyridamole) 25 mg/200 mg capsules, Micardis (telmisartan) tablets, and Micardis HCT (telmisartan/hydrochlorothiazide) 40 mg/12.
A large study showed that Aggrenox
(aspirin/ extended-release dipyridamole) is significantly more effective in preventing a second stroke than aspirin.
BIPI) regarding alleged off-label marketing and deceptive and misleading representations made in BIPIs promotion of four of its prescription drugs: Micardis, Aggrenox
, Atrovent, and Combivent.
Boehringer Ingelheim 00597000160 522,064
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capsules in US