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Related to Allosteric regulation: feedback inhibition, Allosteric enzyme, covalent modification


Of or relating to the binding of a molecule to an enzyme at a site other than the active site, resulting in modulation of the enzyme's activity as a result of a change in its shape.

al′lo·ster′i·cal·ly adv.
al·los′ter·y (ə-lŏs′tə-rē) n.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(Biochemistry) biochem of, relating to, or designating a function of an enzyme in which the structure and activity of the enzyme are modified by the binding of a metabolic molecule
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014


(ˌæl əˈstɛr ɪk, -ˈstɪər-)

of or pertaining to a change in the activity of an enzyme at a site other than the binding site of the substrate.
al`lo•ster′i•cal•ly, adv.
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
References in periodicals archive ?
In PCNs the average shortest path describes the protein attitude to allosteric regulation.
The Monod, Wyman and Changeux theory (MWC) focuses on a particular regulation of biochemical activity, allosteric regulation or, as they themselves call it, the "allosteric mechanism" (Monod, Wyman and Changeux 1965, p.
We propose that another functional role of isoforms may be to serve as a platform for tissue-specific signaling and/or allosteric regulation, since amino acid sequence differences between the isoforms may, for example, affect kinase recognition or allosteric effector molecules such as ATP and ADP (Figure 3).
The study also discusses the long-range quaternary allosteric regulation associated with and very specific to states ED1 and ED2.