The collaboration will focus on the development of novel phospholipid drug conjugates utilizing Orano Med's unique alpha emitter
, lead-212, conjugated to Cellectar's phospholipid ether.
Radium-223 dichloride is an alpha emitter
that selectively targets and binds areas of increased metabolic activity and is approved for the treatment of pain secondary to osteoblastic metastases in the setting of castration-resistant prostate cancer.
Those adult leukemias epide-miologically associated with chronic exposure to cigarettes or contaminated drinking water have cytogenetic characteristics that are typical of an alpha emitter
such as [.sup.210]Po.
Technologies resulting from RAMP research include superconducting materials that can be incorporated into batteries to increase their useful energy significantly and thus extend their life; alpha emitter
batteries that can provide required energy output for years instead of hours or days; and antimatter that has the potential to deliver all the energy required to move, shoot, and communicate for the life of a combat system.
The type of plutonium in the bottle - known as Pu-239 - is a so-called alpha emitter
. These alpha particles are too bulky to penetrate skin or paper, but they can cause poisoning if swallowed or inhaled.