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Related to Alpha synuclein: Lewy bodies


 (ăl′fə-sĭ-no͞o′klē-ĭn, -nyo͞o′-)
A polypeptide protein found primarily in brain neurons but seen also in the fibrils in Parkinson's disease, in the amyloid plaques of Alzheimer's disease, and in brain tissue affected by other neurodegenerative diseases.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
References in periodicals archive ?
Elevated alpha synuclein mRNA levels are associated with craving in patients with alcoholism.
Xia et al., "LK6/Mnk2a is a new kinase of alpha synuclein phosphorylation mediating neurodegeneration," Scientific Reports, vol.
Also, the data showed that the typical accumulation of the disease associated protein alpha synuclein in the brains of Parkinson's Disease animal models was reduced and that expression of a key genetic susceptibility factor, the antioxidant protein, DJ-1, was increased in substantia nigra neurons.
The poisonous chemical, called alpha synuclein, also clumps together in the grey matter of some dementia sufferers.
Brundin, "Parkinson's disease and alpha synuclein: is Parkinson's disease a prion-like disorder?" Movement Disorders, vol.
We conducted a survey in the relevant databases PubMed/ Medline and Scopus for studies up to July 2016 using combinations of the keywords "polymorphism", "alpha synuclein", "SNCA gene", and "Parkinson's disease".
Johnson et al., "Triplication of the normal alpha synuclein gene is a cause of hereditary Parkinson's disease," American Journal of Human Genetics, vol.