macroglobulin

(redirected from Alpha-2 macroglobulin)
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mac·ro·glob·u·lin

 (măk′rō-glŏb′yə-lĭn)
n.
A plasma globulin of high molecular weight.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

macroglobulin

(ˌmækrəʊˈɡlɒbjʊlɪn)
n
1. (Biochemistry) an immunoglobulin of unusually high relative molecular mass, observed in the blood in some diseases
2. (Biochemistry) Also called: immunoglobulin M the normal form of this immunoglobulin
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
References in periodicals archive ?
Increased concentrations of alpha-2 macroglobulin inhibit mesangial proteases, thus retarding the removal of basement membrane.
Some widely used algorithms include the APRI (AST-to-platelets ratio index), the Fibrotest (aptoglobin, alpha-2 macroglobulin, apolipoprotein A1, gamma-glutamyl transpeptidase, and bilirubin), the Hepascore (bilirubin, gamma-glutamyl transpeptidase, haluronic acid, alpha-2 macroglobulin, age, sex), and the BARD (BMI, AST/ALT ratio, diabetes).
In addition, preliminary testing suggests that its lytic activity is localized to the site of delivery because within seconds of moving away from the clot and into the general circulation it is inhibited by alpha-2 macroglobulin, a naturally occurring protein in our blood.
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