The effects and mechanisms of mitochondrial nutrient alpha-lipoic acid
on improving age-associated mitochondrial and cognitive dysfunction: an overview.
Burning mouth syndrome (BMS): double blind controlled study of alpha-lipoic acid
(thioctic acid) therapy.
Radosavljevic, "Alpha-lipoic acid
affects the oxidative stress in various brain structures in mice with methionine and choline deficiency," Experimental Biology and Medicine, vol.
Effect of alpha-lipoic acid
supplementation on oxidative stress markers and antioxidative defense in patients with schizophrenia.
Single dose bioavailability and pharmacokinetic study of a innovative formulation of alpha-lipoic acid
(ALA600) in healthy volunteers.
and Coenzyme Q10 are also widely used antioxidants.
(a- LA; 1,2-dithiolane-3-pentanoic acid, 6,8-dithio-octanoic acid, thioctic acid) is a strong antioxidant that plays an essential role as a cofactor in the metabolism of all organisms, from microorganisms to humans (Navari-Izzo et al., 2002).
Additionally, it contains vitamins A, C, D, B12 and B6, along with copper, zinc, alpha-lipoic acid
New treatments being developed stem from alpha-lipoic acid
, benfotiamine, and aldosterone-reductase inhibitors.
(ALA) is a vitamin-like substance synthesized from octanoic acid in the mitochondrion (Bustamante et al., 1998; Roy and Packer, 1998) and a powerful micronutrient with various biological functions (Kim et al., 2011).
is a potent mitochondrial antioxidant agent that acts by multiple mechanisms promoting anti inflammatory and antithrombotic pathways and positively influencing the nitric oxide mediated vasodilatation .
Ling et al., "Alpha-lipoic acid
pre- and post-treatments provide protection against in vitro ischemia-reperfusion injury in cerebral endothelial cells via Akt/mTOR signaling," Brain Research, vol.