melanocyte-stimulating hormone

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mel·a·no·cyte-stim·u·lat·ing hormone

 (mĕl′ə-nō-sīt′stĭm′yə-lā′tĭng, mə-lăn′ə-)
n. Abbr. MSH
A hormone secreted by the pituitary gland that regulates skin color in humans and other vertebrates by stimulating melanin synthesis in melanocytes and melanin granule dispersal in melanophores. Also called intermedin.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


melanocyte-stimulating hormone: a pituitary gland hormone that causes darkening of the skin by increasing the production of melanin.
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.melanocyte-stimulating hormone - a hormone secreted by the anterior pituitary gland that controls the degree of pigmentation in melanocytes
endocrine, hormone, internal secretion - the secretion of an endocrine gland that is transmitted by the blood to the tissue on which it has a specific effect
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References in periodicals archive ?
[2] Nonstandard abbreviations: DREADD, designer receptors exclusively activated by designer drugs; ARC, arcuate nucleus; PVN, paraventricular nucleus; VMH, ventromedial hypothalamus; LH, lateral hypothalamus; POMC, proopiomelanocortin; CART, cocaine- and amphetamine-related transcript; NPY, neuropeptide Y; AgRP, agouti-related peptide; SIM 1, single-minded homolog 1; [alpha]-MSH, alpha-melanocyte-stimulating hormone; MCH, melanin-concentrating hormone; BDNF, brain-derived neurotrophic factor; NTS, nucleus of the solitary tract; PBN, parabrachial nucleus.
The mechanism of action is thought to be analogous to a peptide alpha-melanocyte-stimulating hormone that is thought to enhance dopamine and norepinephrine, said Dr.
Alpha-melanocyte-stimulating hormone ([alpha]-MSH) is a 13-amino-acid peptide derived from proopiomelanocortin (POMC) [1].
Alpha-melanocyte-stimulating hormone ([alpha]-MSH) is a potent anorexigenic neuropeptide (5); leptin stimulates the production of [alpha]-MSH, which is an agonist for melanocortin-4 receptors (MC4R) and melanocortin-3 receptors (MC3R), and inhibits the production of AgRP (an antagonist for these receptors) in a coordinated manner to regulate the energy balance by inhibiting food intake and stimulating energy expenditure (6).
Leptin is mainly produced by adipocytes and acts via the particular receptor OB-Rb, decreases food intake by motivation the anorexigenic peptide alpha-melanocyte-stimulating hormone peptide ([alpha]-MSH).
L-3,4-dihydroxyphenylalanine (L-DOPA), mushroom tyrosinase (product number: T3824; the activity was [greater than or equal to] 1000 Units/mg), kojic acid, dimethyl sulfoxide (DMSO), 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), alpha-melanocyte-stimulating hormone ([alpha]-MSH), phosphate buffered saline (PBS), Wang resin, triisopropylsilane (TIS), trifluoroacetic acid (TFA), and diethyl ether were purchased from Sigma-Aldrich Co.