The enamelforming cells are called ameloblasts
, and during the process they go through a series of changes that are summarized in the following stages: differentiation, secretion, maturation, and transition.
The epithelial stem cells divide asymmetrically into two cells; the first, called the sister cell, remains in the apical loop and is undifferentiated; the second moves towards the incisive margin and serves as the source of ameloblasts
Other possible causes suggested are: environmen- tal conditions, premature birth, perinatal compli- cations, exposure to dioxine by prolonged breast- feeding, respiratory diseases and oxygen shortage of the ameloblasts
, calcium and phosphate meta- bolic troubles, oxygen starvation associated to low birth weight and febrile childhood diseases.
are cells present during tooth development that secrete large amounts of proteins that later mineralize to form tooth enamel.
Development of enamel is a complex organized process, where the ameloblasts
lay down the enamel rods in an undulating and inter-twining path.
within the developing tooth germ are very sensitive to external stimuli, and many factors can result in enamel abnormalities.
The process of amelogenesis is a complex and regulated by ameloblasts
that requires secretion of certain matrix proteins that includes amelogenins, amelins, enamelins and tuftelins and the previously formed dentine.
The enamel is produced by ameloblasts
(Figure 2D) originated from the inner epithelium of the enamel organ, which is originated from the dental lamina.
are responsible for the formation of enamel, depositing it in rings around the tooth crown beginning at the coronal surface and proceeding to the cervical region.
Vitamin A plays a crucial role in the formation of ameloblasts
As the odontoblasts express BMP, it induces ameloblasts
By tracing the descendants of genetically labeled cells, they also showed that Sox2 positive stem cells give rise to enamel-forming ameloblasts
as well as other cell lineages of the tooth.