Ames test

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Ames test

n.
A test used to determine the mutagenic potential of a substance, in which salmonella bacteria that are unable to synthesize histidine are introduced into the substance, and the substance is deemed mutagenic and carcinogenic if the bacteria regain the ability to synthesize histidine.

[After Bruce Ames (born 1928), American biochemist.]

Ames test

(eɪmz)
n
(Biochemistry) a method of preliminary screening for carcinogens, based on their ability to cause mutations in bacteria
[named after Bruce Ames (born 1928), US biochemist who invented the test]

Ames′ test`

(eɪmz)
n.
a test that exposes a strain of bacteria to a chemical compound in order to determine the potential of the compound for causing cancer.
[1975–80; after Bruce N. Ames (born 1928), U.S. biochemist, who developed the test]
References in periodicals archive ?
As the Ames tests were unequivocally negative (EMEA, 2008), on the basis of the HMPC nonclinical guideline no further genotoxicity testing of valerian root preparations is required (EMEA, 2006b).
Biomonitoring of the genotoxic potential of draining water from dredged sediments, Using the comet and micronucleus tests On amphibian (Xenopuslcevis) larvae and Bacterial assays (mutatox[R] and ames tests).
We have utilized modified Ames tests, superoxide scavenging assays, and assays for protection against DNA scissions to compare and contrast the protective effects of various teas and commercial and laboratory-isolated tea components to those produced by compounds such as resveratrol, selenium, curcumin, vitamins C and E, quercetin dihydrate, sulforaphane, ellagic acid dihydrate, glutathione reduced, trolox, butylated hydroxanisole (BHA), butylated hydroxytoluene (BHT), and N-acetyl-L-cysteine (NAC).