Release date- 13082019 - FOSTER CITY - Terns Pharmaceuticals, Inc., a global biopharmaceutical company focused on discovering and developing innovative therapies to treat non-alcoholic steatohepatitis (NASH) and cancer, today announced the interim results of an ongoing Phase 1 clinical trial of TERN-201, a semicarbazide-sensitive amine oxidase
(SSAO) inhibitor, being developed for the treatment of NASH.
- China- and US-based biopharmaceutical company Terns Pharmaceuticals, Inc has received interim results of an ongoing Phase 1 clinical trial of TERN-201, a semicarbazide-sensitive amine oxidase
inhibitor, being developed for the treatment of NASH, the company said.
These research and development efforts include potential combinations of elafibranor, a dual peroxisome proliferator-activated alpha/delta agonist, with Terns' development candidates, including TERN-101, a farnesoid X receptor agonist, TERN-201, a semicarbazide-sensitive amine oxidase
inhibitor, and their thyroid hormone receptor beta-selective agonist and apoptosis signal-regulating kinase 1 inhibitor programs.
The company said BI 1467335 is an oral inhibitor of amine oxidase
, copper containing 3 (AOC3)1 and works by blocking leucocyte adhesion and tissue infiltration in inflammatory processes underlying NASH.
Microsomal oxidase IV: properties of mixed-function amine oxidase
isolated from pig liver microsomes.
The general trend on an increment of all the biogenic amines after boiling can originate (i) from the possible inactivation of the amine oxidase
enzymes due to high temperature; (ii) from an enhanced availability for extraction, to a more efficient release of biogenic amines from intracellular proteins and altered cell structures ; (iii) from the degradation of other compounds, including precursor amino acids.
Csiszar, "Lysyl oxidases: a novel multifunctional amine oxidase
family," Progress in Nucleic Acid Research and Molecular Biology, vol.
Buffoni, "Monoamine oxidase and semicarbazide-sensitive amine oxidase
activities in isolated cardiomyocytes of spontaneously hypertensive rats," Biochemical and Molecular Medicine, vol.
Global Markets Direct's, 'Lysine-Specific Histone Demethylase 1A (Lysine (K)-Specific Demethylase 1 or Flavin-Containing Amine Oxidase
Domain-Containing Protein 2 or EC 1.) - Pipeline Review, H1 2016', provides in depth analysis on Lysine-Specific Histone Demethylase 1A (Lysine (K)-Specific Demethylase 1 or Flavin-Containing Amine Oxidase
Domain-Containing Protein 2 or EC 1.) targeted pipeline therapeutics.
The following enzymes are known to contribute or have a direct role in metabolism of histamine: monoamine oxidase (MAO), di amine oxidase
(DAO), and histamine N-methyl transferase, aldehyde dehydrogenase.
As inhibitory properties towards pea seedling amine oxidase
of various oxime compounds have been reported in the literature , two selected oxime derivatives of 5-acyl-3- methylsulfanyl-1,2,4-triazine were analyzed toward this end.
Recombinant Saccharomyces cerevisiae yeast was constructed to overproduce primary amine oxidase
(primary amine : oxygen oxidoreductase (deaminating) or amine oxidase
, AMO; EC 220.127.116.11), from the thermotolerant yeast Hansenula polymorpha.