In the first step create a scalable and modular route to multiple new aminoacyl-tRNA
synthetase/tRNA pairs that are orthogonal to each other and to endogenous synthetases and tRNAs.
In October, the Company presented an overview of the therapeutic potential of Resolaris in RMICs at the International World Muscle Congress 2015 in Brighton, UK, as well as a broader overview of the therapeutic potential of Physiocrines at the 10th Annual International Symposium on Aminoacyl-tRNA
Synthetases in Barcelona.
Phosphorylation of aminoacyl-tRNA
synthetases could play a role in the regulation of protein synthesis in a similar manner as insulin regulates muscle (Kimball et al.
It catalyzes the esterification of a specific synthetase (AARS) amino acid or its precursor to one of all its compatible cognate tRNAs to form an aminoacyl- tRNA.
9:30 INVESTIGATING TRNA CHANNELING BY AMINOACYL-TRNA
SYNTHETASES AND ELONGATION FACTOR TU
Therefore, one would expect to observe the impaired translation of an abundant mRNA species containing an excess of rare codons with low aminoacyl-tRNA
The enzyme that catalyzes this amino acid-RNA attachment is the aminoacyl-tRNA
Autoantibodies against aminoacyl-tRNA
synthetase: novel diagnostic marker for type 1 diabetes mellitus.
Cabanas MJ, Vazquez D, and Modolell J: Dual interference of hygromycin B with ribosomal translocation and with aminoacyl-tRNA
Directed at new researchers without the benefit of a couple of decades of work in the field, this explains the initial work of Selman Waksman to produce streptomycin, then proceeds to such topics as the biochemistry and genetics of aminoglycoside producers, mechanics of aminoglycoside antibiotic resistance, the development and action of kanamycin and neomycin class antibiotics, NMR structural studies and RNA interaction, structural comparisons between prokaryotic and eukaryotic ribosomal decoding, binding of antibiotics to the aminoacyl-tRNA
site of bacterial ribosome, the chemistry and biological relevance of metalloaminoglycosides, adverse effects of aminoglycoside therapy, new efforts at targeting HIV-1 RNA, and novel targets for aminoglycosides.
Binding of Antibiotics to the Aminoacyl-tRNA
Site of Bacterial Ribosome (Dale Kling, Christine Chow, and Shahriar Mobashery).
th] Annual International Symposium on Aminoacyl-tRNA
Synthetases (AARS2015), Barcelona, Spain October 18 -- 22, 2015