The company's lead therapeutic candidates, DB-020 and DB-041, are designed to prevent hearing loss resulting from cisplatin and aminoglycoside antibiotics
TRPV4 enhances cellular uptake of aminoglycoside antibiotics
. J Cell Sci 2008; 121: 2871-2879, doi: 10.1242/jcs.023705.
Structural and molecular basis for resistance to aminoglycoside antibiotics
by the adenylyltransferase ANT (2")-Ia.
Under the company's animal studies, ORC-13661 provided highly significant protection of hearing in rats exposed to high doses of aminoglycoside antibiotics
, a common cause of human hearing loss.
aeruginosa were resistant to all aminoglycoside antibiotics
(amikacin, gentamicin, and tobramycin), 45.85% were resistant to a fluoroquinolone antibiotic (ciprofloxacin), 70% were resistant against a third generation cephalosporin (ceftazidime), and 87.5% were resistant to a fourth generation cephalosporin (cefepime).
The parameters for positive results of the tetracycline antibiotics tested are: oxytetracycline (10 [micro]g/kg), tetracycline (10 [micro]g/kg), chlortetracycline (10 [micro]g/kg), and doxycycline (20 [micro]g/kg); the parameters for positive results of the aminoglycoside antibiotics
tested are: dihydrostreptomycin (10 [micro]g/ kg), gentamicin (50 [micro]g/kg), hygromycin (20 [micro]g/kg), kanamycin (20 [micro]g/kg), neomycin (20 [micro]g/kg), paromomycin (25 [micro]g/kg), spectinomycin (50 [micro]g/kg), and streptomycin (20 pg/ kg).
These enzymes possess the ability to reduce the synergetic effect of aminoglycoside antibiotics
on the cell wall of bacteria.
The possible mechanism of our findings is - gentamicin being an aminoglycoside antibiotic
has reduced the synaptosomal calcium availability by acting as an N-type calcium channel blocker and thus decreases neuronal activity [19-21] indicating antagonism between calcium and aminoglycoside antibiotics
Due to the association of aminoglycoside antibiotics
with alterations in electrolyte levels, capreomycin was discontinued.
Although, a host of studies have tested the effect of aminoglycoside antibiotics
on in vitro culture and differentiation [28-31] of stem cells such as bone marrow- or adipose tissue-derived stem cells as well as murine ESCs, as per our knowledge no study has been conducted so far to test the effect of aminoglycoside antibiotics
on hESC proliferation and differentiation.
Repeated courses of aminoglycoside antibiotics
may cause chronic renal insufficiency , but data are controversial .