beta-amyloid

(redirected from Amyloid beta)
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be·ta-am·y·loid

 (bā′tə-ăm′ə-loid′, bē′-)
n.
A protein fragment formed by the cleavage of amyloid precursor protein that aggregates into deposits characteristically found in the brains of people with Alzheimer's disease. Also called amyloid beta-peptide, amyloid beta-protein, beta-amyloid peptide, beta-amyloid protein.

[From the beta sheets characterizing its structure.]
References in periodicals archive ?
Investigating a quartet of mysterious cases in Britain of brain lesions caused by amyloid beta deposits in young adult patients, they found that all four had undergone brain surgery as kids, suggesting a causal link.
Investigators at Brigham and Women's Hospital examined the association of brain amyloid beta and longitudinal measures of depression and depressive symptoms in cognitively normal, older adults.
The results suggest that worsening anxious-depressive symptoms may be an early predictor of elevated amyloid beta levels - and, in turn AD -- and provide support for the hypothesis that emerging neuropsychiatric symptoms represent an early manifestation of preclinical Alzheimer's disease.
According to him, poor UPSIT sores are also related to brain levels of amyloid beta and are almost as predictive of cognitive decline.
PMN310 was designated ProMIS' first lead product candidate in January 2017, based on its ability to selectively bind prion-like forms of Amyloid beta oligomers, a recognized root cause of Alzheimer's disease.
According to William Kriesl, MD, poor UPSIT sores are also related to brain levels of amyloid beta and are almost as predictive of cognitive decline.
AZD3293 has been shown in studies to reduce levels of amyloid beta in the cerebrospinal fluid of people with Alzheimers and healthy volunteers.
Researchers have shown that amyloid beta, a slimy substance found in the brains of people with Alzheimer's disease, protects living mice and cultured human brain cells against brain infections.
The December 2015 issue of The FASEB Journal reports the ability of ionic magnesium (Mg2+) to help reduce the deposition of amyloid beta in an Alzheimer's disease mouse model.
Half were showing clinical signs of AD (such as memory problems), and brain scans indicated that 62 of them had amyloid beta plaques forming in their brains.
Dravid, the research team developed an MRI (magnetic resonance imaging) probe that pairs a magnetic nanostructure (MNS) with an antibody that seeks out the amyloid beta brain toxins responsible for onset of the disease.
Researchers found evidence that amylin was accumulating in the brain and killing neurons, similar to the way amyloid beta does.