These patients had persistent, symptomatic anal fissures
. Informed consent was obtained from all the patients after an explanation of the nature of the disease, treatment method and the possible unwanted effects.
The most recent theories on etiopathogenesis of anal fissures
have focused on increased tonicity of internal anal sphincterotomy, which induces ischemia of the anodermis mainly of the posterior commissure.
It offers its services to women with such symptoms as fecal or urinary incontinence, painful or nonhealing episiotomy, anal fissures
, third-or fourth-degree lacerations, rectovaginal fistulas, postpartum urinary retention, pelvic organ prolapse, and painful intercourse.
The pharmaceutical company's product pipeline consists of three late-stage topical treatment candidates: an iferanserin ointment for hemorrhoids; a diltiazem cream for pain associated with anal fissures
; and a phenylephrine gel for fecal incontinence.
Anal disorders in HIV-positive patients (most often found in combination) Disorder Average incidence (%) Proctitis/skin involvement 40 Condylomata acuminata 43 Fissure-in-ano 30 Anal ulcer 29 Haemorrhoids 15 Chlamydia/gonorrhoea 2 Kaposi's sarcoma 2 Squamous cell carcinoma 1 Condyloma acuminatum (human papilloma-virus) is the most common finding (40-50%) in many series, followed by peri-anal ulcers (32%), fistula-in-ano (30%), anal fissures
(30%), sepsis and abscesses, complicated haemorrhoids and proctocolitis.
Acute anal fissures
often heal spontaneously or with the help of medical treatment.
Add scrotal dependencies, testicular scrums, turdlike masses, anal fissures
, gingery tubers, and intestinal buntings, and you can easily see how repugnant all this could be.
Patients with anal fissures
describe severe pain, bright red blood from the rectum, and pain for 3-4 hours following a bowel movement.
Other findings included colitis, angiodysplasia, diverticulosis, anal fissures
, and rectal ulcers.
Trauma of running may produce bleeding from hemorrhoids or anal fissures
. Direct trauma to viscera may also cause injury.
The disorders disclosed in the patent include anal fissures
, hemorrhoids and constipation.