anandamide


Also found in: Medical, Wikipedia.

anandamide

a derivative of arachidonic acid that occurs naturally in the brain and in some foods, such as chocolate, and that binds to the same brain receptors as cannabinoids (the chemical compounds that are the active principles of marijuana)

a·nan·da·mide

 (ə-năn′də-mīd′)
n.
A neurotransmitter, C22H37NO2, found especially in the brain, that binds to the same receptors as cannabinoids and influences mood, appetite, motivation, perception of pain and pleasure, and memory. Anandamide is also found in small amounts in cocoa and chocolate.

[Sanskrit ānandaḥ, bliss (ā, to, until + nandati, he is happy) + amide.]

anandamide

(əˈnændəˌmaɪd)
n
(Biochemistry) a naturally occurring endogenous cannabinoid neurotransmitter found in the brains of mammals and in small quantities in the cocoa bean
[C20: from Sanskrit ananda bliss]
References in periodicals archive ?
Anandamide, generally referred to as AEA, is one of the cannabinoids that the human body makes naturally.
The endocannabinoids alkylamides and anandamide (AEA) are found in echinacea, bind to the CB2 receptor and, like the THC cannabinoid, greatly inhibits inflammation.
Cannabidiol also inhibits an enzyme that metabolizes the endocannabinoid anandamide, which are neurotransmitters produced throughout the central nervous system, including the brain.
This enzyme is responsible for the degradation of endocannabinoids and is encoded by its homonym gene FAAH which presents a missense SNP (rs324420/C385A) that reduces the expression and the activity of that enzyme, resulting in increased anandamide levels (Chiang, Gerber, Sipe, & Cravatt, 2004; Dincheva et al, 2015).
Sheep cheese naturally enriched in [alpha]-linolenic, conjugated linoleic and vaccenic acids improves the lipid profile and reduces anandamide in the plasma of hypercholesterolaemic subjects.
All human beings have an endocannabinoid system, which naturally produces cannabis-like compounds, the main ones being anandamide and 2-arachidonoylglycerol (2-AG) that bind to their receptors to produce beneficial effects.
(31-32) In addition, CBD increases the availability of the endogenous cannabinoid anandamide, which may have antipsychotic properties.
CBD stimulates the body to release anandamide, a neurotransmitter produced in the brain.
There exist also endogenous cannabinoids eg., arachidonoyl ethanolamide or anandamide and arachidonoylglycerol.
Combining CBD with chocolate helps prolong and double the effect of anandamide, a cannabinoid found in dark chocolate that works as the body's own antidepressant and pain reliever, resulting in a calm, soothing effect.
Anandamide (N-aracuidonoyl etanolamine) and 2-aracuidonoyl glycerol both belong to the group of endocanabinnoids that are synthesized by neurons in the brain (MASSI et al., 2012; BRUCKI et al., 2015; LESSA et al., 2016) and are released by excitatory synaptic stimuli (BRUCKI et al., 2015).