OBJECTIVE: The beneficial effect of the natural compound propionyl-l-carnitine (PLC) on intermittent claudication in patients with peripheral arterial disease is attributed to its anaplerotic
function in ischemic tissues, but inadequate information is available concerning action on the vasculature.
Experimental observation suggests that both anaplerotic
reactions and glyoxalate cycle play an important role for the production of tricarboxylic acid (TCA) cycle derived amino acids (aspartate which is a precursor of lysine and glutamate families) (Petersen, et al.
Perspective: Emerging evidence for signaling roles of mitochondrial anaplerotic
products in insulin secretion.
Increased lactate concentration is an anaplerotic
effect of alkalaemia (33,34), operating as a feedback loop which buffers pH swings (35,36).
Non-autotrophic uses of dark-fixed carbon include involvement as a pH stat mechanism for reducing cytoplasmic ionic disequilibrium (Raven, 1986) or in anaplerotic
reactions related to nitrogen assimilation (Turpin et al.