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The antiepileptic effects of stimulation of the anterior nucleus of the thalamus (ANT) have been demonstrated by clinical trials and animal studies.
In the Medtronic-funded Stimulation of the Anterior Nucleus of the Thalamus for Epilepsy (SANTE) study, 110 patients with medically refractory partial seizures were implanted with the device and randomized to intermittent bilateral stimulation (1 minute on/5 minutes off) or no stimulation for a 3-month blinded stage, followed by unblinded stimulation for all of the patients (Epilepsia 2010;51:899-908).
The components of the DBS system include a neurostimulator that connects to two leads that are implanted in the anterior nucleus of the thalamus.
The FDA panel reviewed data from a US clinical trial called SANTE (Stimulation of the Anterior Nucleus of the Thalamus in Epilepsy) involving 110 patients from 17 US trial centers who had severe epilepsy for an average of 22 years prior to study enrollment.
9) It possesses a single anterior nucleus, a rod-like axostyle, undulating memberane and five flagella.
Identification of the anterior nucleus of the ansa lenticularis in birds as the homolog of the mammalian subthalamic nucleus.