(2) In addition, many of the current anticonvulsants
have various complications and serious side effects such as hepatotoxicity and agranulocytosis, (1, 3, 4) which necessitates new drugs with more suitable margins of safety and more tolerability.
Franklin, "Experimental selection, quantification and evaluation of anticonvulsants
," in Antiepileptic Drugs, Raven Press, New York, NY, USA, 1989.
George, "Hepatotoxicity of commonly used drugs: nonsteroidal anti-inflammatory drugs, antihypertensives, antidiabetic agents, anticonvulsants
, lipid-lowering agents, psychotropic drugs," Seminars in Liver Disease, vol.
With a history of seizures, she also took several anticonvulsants
throughout her pregnancy.
also might increase resistance to pseudohypoparathyroidism and inhibit calcitonin secretion.
Our patient was given anticonvulsants
for her seizures, which may have resulted in the delay of her diagnosis.
Popp, Potential anticonvulsants
VI: Condensation of isatins with cyclohexanone and other cyclic ketones, J.
are used to prevent and treat mood episodes.
Nine out of 12 patients received antihypertensive agents to control the blood pressure, and 8 out of the 12 patients received anticonvulsants
to manage seizures.
In this study on the patients who were admitted to the emergency department of DEUH due to anticonvulsant
overdose, only blood carbamazepine, valproic acid, phenytoin and phenobarbital levels could be measured in the DEUH laboratories, serum levels of the other anticonvulsants
could not be measured.
While hypersensitivity drug reactions are well known, the hereditary component of AHS remains unfamiliar to physicians who prescribe anticonvulsants
, as demonstrated by our case.