antigenic determinant

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antigenic determinant

(Biochemistry) the specific part of an antigen molecule to which an antibody becomes attached


(ˈɛp ɪˌtoʊp)

a site on an antigen at which an antibody can bind, the molecular arrangement of the site determining the specific combining antibody. Also called antigenic determinant .
[1970–75; epi- + -tope < Greek tópos place; compare topo-]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.antigenic determinant - the site on the surface of an antigen molecule to which an antibody attaches itself
immunology - the branch of medical science that studies the body's immune system
site, situation - physical position in relation to the surroundings; "the sites are determined by highly specific sequences of nucleotides"
antigen - any substance (as a toxin or enzyme) that stimulates an immune response in the body (especially the production of antibodies)
References in periodicals archive ?
RED BLOOD CELLS CONCENTRATE (SERASCAN) (vial presentation (I and II) with 10 ml of human erythrocytes group 0, with more significant antigenic determinants of most of the blood group systems.
Langerhans cells have cytoplasmic inclusion bodies known as Birbeck granules; a definitive diagnosis requires electron microscopy of Birbeck granules or CD 1 antigenic determinants by immunohistochemistry.
These include developing highly specific immunogens that mimic the antigenic determinants recognized by broadly neutralizing antibodies found in infected people.
The L segment encodes the RNA-dependent RNA polymerase; antigenic determinants are the M-encoded viral surface glycoproteins Gn and Gc, which are responsible for viral attachment, cell fusion, hemagglutination, and the induction of neutralizing antibodies, and the S-encoded nucleocapsid protein N, which plays a role in complement fixation (6).
Glycophorins of human erythrocytes, carry blood group antigenic determinants and serve as receptors for viruses, bacteria and parasites, have been thoroughly studied (Kumar et al.
Penicillin is metabolised into major (penicilloyl) and minor (penicilloate and penilloate) antigenic determinants.
Thomas Jefferson University (Philadelphia, PA) has patented live, attenuated recombinant rabies virus vaccines generated using reverse genetics to combine the antigenic determinants that render the rabies virus non-pathogenic with the determinants that are responsible for the elicitation of an effective anti-rabies immune response.