antimycin

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Related to Antimycin A: Oligomycin

antimycin

(ˌæntɪˈmaɪsɪn)
n
an antibiotic drug active against various fungi
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
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Noun1.antimycin - a crystalline antibiotic active against various fungi
antibiotic, antibiotic drug - a chemical substance derivable from a mold or bacterium that can kill microorganisms and cure bacterial infections; "when antibiotics were first discovered they were called wonder drugs"
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
Many mitochondrial poisons are known complex inhibitors (e.g., rotenone and antimycin A) and uncouplers (e.g., 2,4-dinitrophenol and carbonyl cyamide 4-(trifluoromethoxy)phenylhydrazone, or FCCP) of oxidative phosphorylation.
RCC I activity was measured using a buffer containing 25 mM potassium phosphate (K[H.sub.2]P[O.sub.4]/ [K.sub.2]HP[O.sub.4]); 5 mM magnesium chloride (Mg[Cl.sub.2]), pH 7.2, 0.25% bovine serum albumin (BSA; Sigma-Aldrich); 0.13 mM b-nicotinamide adenine dinucleotide, reduced dipotassium salt (NADH, SigmaAldrich); 2 mM potassium cyanide (KCN, Sigma-Aldrich); 2 [micro]g/mL antimycin A (Sigma-Aldrich); and 65 [micro]M ubiquinone 1 (Sigma-Aldrich), which was supplemented with or without 2 [micro]g/mL rotenone (Sigma-Aldrich).
Among the compounds that decreased MMP were several well-known mitochondrial toxicants including FCCP and antimycin A. We retested the 622 compounds in the HepG2 cell MMP assay using existing Tox21 10K library stock solutions.
Moreover, PQQ protected cells from mitochondrial inhibition by rotenone, 3-nitropropionic acid, antimycin A, and sodium azide.