PhaseBio Pharmaceuticals announced that data from an evaluation of the pharmacodynamics of PB2452, a novel reversal agent for the antiplatelet drug
ticagrelor, were presented by Lisa K.
In a previous case report, the catheter was removed after 72 h of withholding a dual antiplatelet drug
Clopidogrel is a cornerstone antiplatelet drug
that is used by millions of patients worldwide especially those suffering from heart attacks.
Figure shows the frequencies of different antiplatelet drug
regimens prescribed to our study population.
For the time being, clopidogrel is the evidence-based antiplatelet drug
to pair with aspirin for this indication.
Even when handed information on whether each clopidogrel-treated patient was a poor metabolizer of the drug, treating physicians usually did not switch them to a different antiplatelet drug
, ticagrelor, that would be fully effective despite the patient's reduced-metabolizer status.
The settlement alleges that the company misrepresented its antiplatelet drug
, Aggrenox, that was effective for many conditions 'below the neck,' such as heart attacks and congestive heart failure, and that it was superior to Plavix, without evidence to substantiate that claim; misrepresented that Micardis protected patients from early morning strokes and heart attacks and treated metabolic syndrome; misrepresented that Combivent could be used as a first-line treatment for bronchospasms associated with chronic obstructive pulmonary disease (COPD); Falsely stated that Atrovent and Combivent could be used at doses that exceeded the maximum dosage recommendation in the product labelling and that the drugs were essential for treatment of COPD.
Aspirin helps prevent platelets in the bloodstream from clumping together and forming a clot, so it is called an antiplatelet drug
; other antiplatelet drugs
include Clopidogrel (Plavix) and ticagrelor (Brilinta).
Second, the antiplatelet drug
history came from the patient (or carer) reflecting their memory of what had been taken recently, and it was not possible to confirm this by direct measurement of drugs or metabolites.
Wei, "Antiplatelet drug
interactions," Journal of Internal Medicine, vol.
Ferro, "Antiplatelet drug
resistance: molecular insights and clinical implications," Prostaglandins and Other Lipid Mediators, vol.