They then initiated daily antiretroviral therapy
(ART) for 96-weeks, during acute infection to suppress the virus to below detectable levels in the monkey's blood.
2,4) Researchers working with the Antiretroviral Therapy
Cohort Collaboration (ART-CC) conducted a large and detailed study covering people starting ART between 1996 and 2010.
This study highlights that oral lesions especially oral candidiasis are decreased after antiretroviral therapy
while some lesions especially oral pigmentation has been significantly increased which may be due to the side effects of this therapy.
General practice has been to defer antiretroviral therapy
until CD4+ counts decline to a certain threshold level--a level that has changed over time and that varies across different treatment guidelines.
To address this knowledge gap, researchers in the International Network for Strategic Initiatives in Global HIV Trials (INSIGHT) designed and conducted the Strategic Timing of Antiretroviral Therapy
(START) trial, which compared the benefits and risks of immediate initiation of antiretroviral therapy
in patients with CD4+ counts above 500 cells/cc (2,326 patients) against deferring therapy until CD4+ counts declined to 350 cells/cc (2,359 patients).
In all study areas, participants with positive test results could go to a study clinic to have their results confirmed and begin antiretroviral therapy
if eligible (i.
According to the researchers from University of North Carolina and NIH, such a targeted poison could complement antiretroviral therapy
, which dramatically reduces the replication of HIV in infected cells but does not eliminate them.
In its first consolidated guidelines on the use of antiretroviral therapy
to treat HIV, WHO estimated that earlier treatment could prevent 3 million deaths and 3.
New guidelines from WHO, issued together with the report, give clear recommendations that people living with HIV should start antiretroviral therapy
much earlier, and immediately in some instances.
WHO guidelines issued in 2009 recommended antiretroviral therapy
for people with a CD4 cell count below 350 cells/m[m.
Disorders of immune reconstitution in patients with HIV infection responding to antiretroviral therapy
With the rapid scaleup of antiretroviral therapy
in India both in the public and private sectors, more patients are benefited.