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n.1.(Chem.) A bitter principle obtained from the dogbane (Apocynum cannabinum).
References in periodicals archive ?
Apocynin prevents cyclooxygenase 2 expression in human monocytes through NADPH oxidase and glutathione redox-dependent mechanisms.
Background: Pure apocynin, which can be traditionally isolated and purified from several plant species such as Picrorhiza kurroa Royle ex Benth (Scrophulariaceae), acts as an inhibitor of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) activity inhibiting its production of reactive oxygen species (ROS).
The effect of natural antioxidants, NOA and apocynin, on oxidative stress in the rat heart following LPS challenge.
BMP4's role on the activation of NADPH oxidases and impairment of vasorelaxation has also been demonstrated along with the prevention of hypertension by apocynin treatment (Apocynin is the inhibition of the NADPH oxidases) (4).
Co-administration of apocynin with lipoic acid enhances neuroprotection in a rat model of ischemia/reperfusion.
Importantly, inhibition of NOX by apocynin significantly protected against PCB-mediated increase in epithelial permeability and alterations of ZO-1 protein expression.
L-NAME, dexamethasone (Dex), apocynin, LPS, lucigenin, quercetin, MTT andJC-1 were purchased from Sigma-Aldrich (St.
Our results showed that inhibition of NADPH oxidase activity ameliorated cerebral ischaemia/reperfusion (I/R) injury and among Zn(2+) -dependent HDACs, HDAC4 and HDAC5 were significantly decreased both in vivo and in vitro, which can be reversed by NADPH oxidase inhibitor apocynin.
5A, BFP-induced IRE1 increase, and procaspase-3 and procaspase-9 degradation were reversed by treatment with two different antioxidants apocynin (10 [micro]M) and N-acetylcysteine (NAC, 10 mM).
7 macrophages and this effect was reverted by apocynin, a NADPH oxidase inhibitor.