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n.1.(Chem.) A bitter principle obtained from the dogbane (Apocynum cannabinum).
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Other promising treatment modalities include PGI2, magnesium sulphate, bosentan, adenosine, steroids and apocynin, but there is insufficient evidence to recommend any for routine or combination use (Table 7).
Since, targeting the contributors of ROS is the best strategy, therefore many studies have explored potential of apocynin (inhibitor of NADPH oxidase) (Li et al.
Summary: The ethyl acetate soluble fraction of the methanolic extract of Vincetoxicum stocksii yielded four new compounds; vincetolate (1), vincetoside (2), vincetetrol (3) and vincetomine (4) along with seven know compounds; 1-(4-hydroxy-3-methoxyphenyl)-1,2,3,-propanetriol (5), feruloyl-6-O-b-D-glucopyranoside (6), apocynin (7), 4-hydroxy-3,5-dimethoxybenzoic acid (8), 7-megastigmene-3,5,6,9-tetrol (9), qurcetin-3-O-b-D-glucopyranoside (10) and 4-methoxykaempferol-3-O-b-D-glucopyranoside (11).
Apocynin prevents cyclooxygenase 2 expression in human monocytes through NADPH oxidase and glutathione redox-dependent mechanisms.
Apocynin administration prevents the changes induced by a fructose-rich diet on rat liver metabolism and the antioxidant system.
The effect of natural antioxidants, NAO and apocynin, on oxidative stress in the rat heart following LPS challenge.
The effect of natural antioxidants, NOA and apocynin, on oxidative stress in the rat heart following LPS challenge.
BMP4's role on the activation of NADPH oxidases and impairment of vasorelaxation has also been demonstrated along with the prevention of hypertension by apocynin treatment (Apocynin is the inhibition of the NADPH oxidases) (4).
Background: Pure apocynin, which can be traditionally isolated and purified from several plant species such as Picrorhiza kurroa Royle ex Benth (Scrophulariaceae), acts as an inhibitor of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) activity inhibiting its production of reactive oxygen species (ROS).