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 (ăp′əp-tō′sĭs, ăp′ə-tō′-)
A natural process of self-destruction by degradative enzymes in certain cells, such as epithelial cells and erythrocytes, that are genetically programmed to have a limited lifespan or are damaged, as by irradiation or toxic drugs. Also called programmed cell death.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(Biology) biology the programmed death of some of an organism's cells as part of its natural growth and development. Also called: programmed cell death
[C20: from Greek: a falling away, from apo- + ptōsis a falling]
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.apoptosis - a type of cell death in which the cell uses specialized cellular machinery to kill itself; a cell suicide mechanism that enables metazoans to control cell number and eliminate cells that threaten the animal's survival
cell death, necrobiosis - (physiology) the normal degeneration and death of living cells (as in various epithelial cells)
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
It decreased phosphorylation of signal transducer and activator of transcription (STAT3/5) proteins, inhibited cell proliferation and induced apoptotic cell death in cell models expressing mutationally active JAK2 or FLT3.
Apoptotic cell death has been demonstrated as the main mechanism of germ-cell loss in the perinatal period.
In one model; the main role of the P53 pathway in determining cell destiny has been suggested either to activate the control points in the cell cycle or facilitate repair, thereby increasing survival or, inducing apoptotic cell death (28-30).
Apoptotic cell death was determined using annexin-V-fluorescein isothiocyanate (FITC)/7-amino-actinomycin D (7-AAD; BD Biosciences) and Cycletest[TM] Plus DNA Reagent Kit (BD Biosciences) in all cells.
"Metformin also induced endoplasmic reticulum stress and subsequent apoptotic cell death via the activation the proapoptotic family members," she said.
They exhibit decreased apoptotic cell death, compared with normal skin.
The authors then examined their effects on the MSC in various biological processes, showing that PCA-polymerized CNTs are less cytotoxic and lead to less apoptotic cell death. The effects of nitrogen-doped CNTs (CNxs) are also reported.
The onset of cancer usually results from uncontrolled cell proliferation or an inability of cells to undergo apoptotic cell death (Herr and Debatin, 2001).
Caspases are proteases which play critical role in the initiation and execution of apoptotic cell death.14
Approaches in activating NRF2, such as administration of the NRF2 activator sulforaphane (SFN) [5, 6], supplementation of zinc [15], and exposure to low-dose X-irradiation [8], effectively ameliorated diabetes-induced testicular inflammation, ER stress, and apoptotic cell death, in rodent models of both type 1 and type 2 diabetes.
These results suggest that NnV strongly inhibits the growth of HepG2 cells through induction of apoptotic cell death, but not that of normal cells.
Caspase-3, being the main executioner of apoptotic machinery, cleaves PARP and other effector proteins, ultimately leading to apoptotic cell death [16, 18].

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