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 (ăp′əp-tō′sĭs, ăp′ə-tō′-)
A natural process of self-destruction by degradative enzymes in certain cells, such as epithelial cells and erythrocytes, that are genetically programmed to have a limited lifespan or are damaged, as by irradiation or toxic drugs. Also called programmed cell death.


(Biology) biology the programmed death of some of an organism's cells as part of its natural growth and development. Also called: programmed cell death
[C20: from Greek: a falling away, from apo- + ptōsis a falling]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.apoptosis - a type of cell death in which the cell uses specialized cellular machinery to kill itself; a cell suicide mechanism that enables metazoans to control cell number and eliminate cells that threaten the animal's survival
cell death, necrobiosis - (physiology) the normal degeneration and death of living cells (as in various epithelial cells)
References in periodicals archive ?
They exhibit decreased apoptotic cell death, compared with normal skin.
The onset of cancer usually results from uncontrolled cell proliferation or an inability of cells to undergo apoptotic cell death (Herr and Debatin, 2001).
Caspases are proteases which play critical role in the initiation and execution of apoptotic cell death.
However, intact DNA fragments detected evidence of apoptotic cell death, and it was found that their residues were gradually increasing from the beginning of reperfusion up to 72 hours in our groups (primary PCI group 0.
Eribulin is a microtubule dynamics inhibitor that is likely to work mainly through a tubulin-based mechanism that causes prolonged and irreversible mitotic blockage, leading to apoptotic cell death.
Morphological observation of DAPI and acridine orange/propodium iodide staining documented typical characteristics of apoptotic cell death.
Several studies showed that wild type p53 is required for the apoptotic cell death particularly if induced by some anticancer drugs through several pathways [1,2] and [3].
We employed flow cytometry to detect INS-1 apoptotic cell death after dexamethasone and ghrelin treatment.
Although cellular loss via apoptotic cell death has a fundamental impact on plaque stability, this effect depends on the stage of plaque development and the cell type that is involved.
They provide the cellular energy required by these cells and protect them by buffering potentially lethal levels of cytoplasmic calcium, while at the same time mitochondria produce much of the molecules that cause cellular damage and contain a lethal arsenal of apoptotic cell death machinery.
Furthermore, PC-3 cells after incubation with quercetin for 48 h showed an apoptotic cell death and DNA damage which are confirmed by DAPI and Comet assays, leading to decrease the antiapoptotic Bcl-2 protein and level of DY(m), and increase the proapoptotic Bax protein and the activations of caspase-3, -8, and -9.

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