(redirected from Apoptotic cell death)
Also found in: Thesaurus, Medical, Encyclopedia.


 (ăp′əp-tō′sĭs, ăp′ə-tō′-)
A natural process of self-destruction by degradative enzymes in certain cells, such as epithelial cells and erythrocytes, that are genetically programmed to have a limited lifespan or are damaged, as by irradiation or toxic drugs. Also called programmed cell death.


(Biology) biology the programmed death of some of an organism's cells as part of its natural growth and development. Also called: programmed cell death
[C20: from Greek: a falling away, from apo- + ptōsis a falling]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.apoptosis - a type of cell death in which the cell uses specialized cellular machinery to kill itself; a cell suicide mechanism that enables metazoans to control cell number and eliminate cells that threaten the animal's survival
cell death, necrobiosis - (physiology) the normal degeneration and death of living cells (as in various epithelial cells)
References in periodicals archive ?
Growth inhibition of HL-60 cells that was triggered by parvifloron D was found to be caused by a rapid induction of apoptotic cell death.
005) increase in caspase-3, a marker associated with apoptotic cell death.
They provide the cellular energy required by these cells and protect them by buffering potentially lethal levels of cytoplasmic calcium, while at the same time mitochondria produce much of the molecules that cause cellular damage and contain a lethal arsenal of apoptotic cell death machinery.
Furthermore, PC-3 cells after incubation with quercetin for 48 h showed an apoptotic cell death and DNA damage which are confirmed by DAPI and Comet assays, leading to decrease the antiapoptotic Bcl-2 protein and level of DY(m), and increase the proapoptotic Bax protein and the activations of caspase-3, -8, and -9.
Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction.
Apoptotic cell death is preferred over necrotic cell death, since necrosis is associated with sustained inflammatory cell damage caused when necrosed cells swell and undergo lysis to spew their cytoplasmic contents.
Our results indicate that moderate alcohol consumption may have protective effects on apoptotic cell death after traumatic brain injury," the authors wrote.
have indicated that hyperthermia increased the brain damage of immature rats and determined the mechanism of apoptotic cell death (19).
Our results suggest that the control of apoptosis is highly complex in the coral-algae symbiosis and that apoptotic cell death cascades potentially play key roles in tipping the cellular life or death balance during environmental stress prior to the onset of coral bleaching," explained lead author Dr Tracy Ainsworth.
TNF-[alpha] is an important immunoregulatory cytokine that induces apoptotic cell death.
Alzheimer's disease (AD) and age-related macular degeneration (AMD) share several pathological hallmarks including [beta]-amyloid (A[beta]) accumulation, oxidative stress, and apoptotic cell death.
Moreover, other studies indicate that accumulation of autophagic vacuoles can precede apoptotic cell death (CUI et al.

Full browser ?