arachidonic acid

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Related to Arachidonate: Phosphatidate

ar·a·chi·don·ic acid

An unsaturated fatty acid, C20H32O2, present in animal fats and synthesized by the body from linoleic acid, that is essential in human nutrition and is a precursor in the biosynthesis of some prostaglandins.

[From arachidic, of the groundnut, from New Latin Arachis, groundnut genus, from Greek arakis, arakid-, diminutive of arakos, a leguminous plant.]

arachidonic acid

(Biochemistry) a fatty acid occurring in animal cells: the metabolic precursor of several groups of biologically active substances, including prostaglandins
References in periodicals archive ?
These included Methyl laurate (25), methyl myristate (33) and myristic acid (34), methyl iso-pentadecanoate (37), methyl pentadecylate (40), isopropyl myristate (41), methyl palmitoleate (46), palmitoleic acid (49), methyl palmitate (47) and palmitic acid (51), methyl margarate (52), methyl linoleate (54), methyl oleate (55), Oleic acid (59), methyl elaidate (56), methyl stearate (58), methyl 9Z,12E-Octadecadienoate (60), methyl arachidonate (63), gondoic acid (64), methyl arachidate (65), methyl erucate (69), methyl behenate (70), and methyl lignocerate (75).
2][gamma]) by divalent cations mediating arachidonate release and production of downstream eicosanoids.
10] Furthermore, it is shown to influence platelet production and aggregation by activating arachidonate 12-lipoxygenase (ALOX 12) and platelet-activating factor receptor (PTAFR) genes.
5-oxo-ETE is a major oxidative stress-induced arachidonate metabolite in B lymphocytes.
Enrichment of endothelial cell arachidonate by lipid transfer from high density lipoproteins: relationship to prostaglandin I2 synthesis.
Respiratory tract diseases: After a careful inspection of our network, we find that a number of targets related to a large number of compounds that could possibly be developed to treat respiratory tract diseases, these include: Radix Isatidis, including Prostaglandin G/H synthase 1 (T2), peroxisome proliferator activated receptor gammareceptor (T13), arachidonate 5-lipoxygenase (T17), deltatype opioid receptor (T27),cGMP-inhibited 3',5'-cyclic phosphodiesterase A (T29), muscarinic acetylcholine receptor M2 (T37), beta-2 adrenergic receptor (T39), tumor necrosis factor (T44), mu-type opioid receptor (T49), mitogen-activated protein kinase 14 (T58), transcription factor AP-1 (T60) and E-selectin (T62).
Tenders are invited for Supply of Methyl linoleate (C18:2 cis-9,12 ),Methyl linolenate (C18:3 cis-6,9,12 ),Methyl linolenate (C18:3 cis-9,12,15 ), Methyl arachidonate (C20:4 cis-5,8,11,14 ),Methyl cis-5,8,11,14,17-eicosapentaenoate (C20:5), Methyl cis-4,7,10,13,16,19-docosahexenoate (C22:6,Methyl palmitate (C16:0) ,Methyl stearate (C18:0),Methyl oleate (C18:1 cis-9 ) ,GC Multi-residues Mixtures Organophosphorous (10-30 compounds), 95-100% purity, 100-1000 g/ml.
The mRNA and hormone levels of arachidonate acid pathways were studied via quantitative reverse transcription PCR (qRT-PCR) and ELISA.
Lysolecithin is generated in LDL particle as a result of the lipid peroxidation, and the concentration of esterified cholesterol is reduced, a number of lipid-derived oxidation products are formed, including lipid hydroperoxides, and specific products of linoleate and arachidonate oxidation are formed, including 9-hydroxy-10,12-octadecadienoic acid (9-HODE) and F2-isoprostanes [70,71].
19 TQ also inhibits the synthesis of prostaglandins (PGEs) and LTs by blocking the cycloxygenase (COX) and lipoxygenase (LO) pathways of arachidonate metabolism, and is thus responsible for anti- inflammatory activity.
In addition, diclofenac appears to reduce the intracellular concentration of free arachidonate in leukocytes, perhaps by altering the release or uptake of the fatty acids (Reiss et al.