The aromatase inhibitors
are the new development in the endocrine treatment of breast cancer.
CYP1A, 2B, 3A)-mediated metabolism in mammals and other non-targeted organisms, and these chemicals are also known as aromatase inhibitors
(AIs) which block cytochrome P450 aromatase (P450arom) activity, resulting in a decrease in estrogen production (Allen et al.
work by blocking the production of the hormone oestrogen, stopping its ability to fuel some breast cancers.
The appraisal committee acknowledged that the treatment was able to stop disease progression by three months verses aromatase inhibitors
, however the committee rejected it because current efficacy data is not extensive enough to suggest its use would cause better overall survival in comparison to existing therapies.
In women diagnosed with breast cancer, taking tamoxifen and/or aromatase inhibitors
reduces the risk of developing cancer in their other breast, according to a study published online Oct.
In two large studies published in The Lancet, a class of hormone therapy drugs called aromatase inhibitors
and bone-preserving drugs called bisphosphonates improved survival and recurrence rates in postmenopausal women with early breast cancer.
The findings are expected to influence clinical guidelines on prescribing aromatase inhibitors
, which were already known to be effective at preventing cancer recurrence.
Estrogens are thought to help close epiphyseal growth plates; the idea of giving aromatase inhibitors
(AIs) is to block aromatase from converting androgens to estrogens in boys so that their growth plates stay open a bit longer and they grow taller.
Risk was comparable in women on aromatase inhibitors
(AIs) only and in those who used sequential tamoxifen followed by an AI, Reina Haque, Ph.
At the same time, use of aromatase inhibitors
(AIs) for sex reversal have also been attempted in mammals , birds (chickens) [5,6], amphibians , reptiles  and fishes .
Pre- and perimenopausal women can be given tamoxifen but not aromatase inhibitors
; postmenopausal women can be given either agent, but the total duration of aromatase inhibitors
shouldn't exceed 5 years, Dr.
Anastrozole is one of a class of medications called aromatase inhibitors
, and these drugs stop the body from producing estrogen.