50] values of 10 artemisinin derivatives (artesunate, artemether
, arteether, artenimol, artemisitene, arteanuin B, another monomeric artemisinin derivative and three artemisinin dimer molecules) were correlated to the microarray-based mRNA expression of 30 iron-related genes in 60 cell lines of the National Cancer Institute (NCI, USA) as determined in 218 different microarray hybridization experiments.
Artesunate was obtained from Sanofi (Paris, France) and artemether
from Rhone Poulenc Rorer (Paris, France).
falciparum ATPase6 gene is associated with raised artemether
half maximal inhibitory concentration ([IC.
Evaluation of biochemical indices following administration of artemether
, halofantrine and a combination of artemether
and lumefantrine in guinea pigs.
is recommended by the World Health Organization (WHO) for resistance to cerebral malaria .
-Lumefanthrine is a fixed dose combination tablet containing artemether
Injections, Artesunate Tablets, Dihydroartemisinin Powder for Suspension, and many other Antimalarial products are now in the hands of those that need it most.
The new treatment, combining pyronaridine and artesunate, was tested at seven sites in Africa and three in Southeast Asia alongside the standard drugs, artemether
and lumefantrine, BBC reported.
The study concerned versions of such widely used and trusted medications as sulfadoxine-pyrimethamine, amodiaquine, mefloquine, artesunate, artemether
, dihydroartemisinin and artemether
-lumefantrine fixed-dose combinations.
The Swiss drugmaker is seeking FDA approval for the drug, which combines artemether
and lumefantrine, to treat acute, uncomplicated malaria infections.
Effect of artemether
alone and incombination with grape fruit juice on hepatic drug-metabolizing enzymes and biochemical aspects in experimental Schistosoma mansoni.
Several derivatives of this have been produced of which two have been recently marketed in India: Artemether
which is soluble in oil and Artesunate (Sod) which is water soluble.