Apart from olive leaves, people can grow their own Artemisia annua
or afra bushes and make tea or use the powdered dry leaves, mixed with honey, to fight malaria.
One of the compounds they identified was artemisinin, an extract of Artemisia annua
Composition of the essential oil from the root of Artemisia annua
. Journal of Natural Medicines-Tokyo 61: 458-461.
The most famous among them is Artemisia annua
L., sweet wormwood, a highly aromatic herb of Asian and Eastern European origin that is nowadays naturalized worldwide.
Recently, an integrated proteomic and metabolomics research demonstrated that a combination of natural products comprising of Rheum palmatum L., Gardenia jasminoides Ellis, and Artemisia annua
L., had an improved therapeutic effect on hepatic injury syndrome through regulating dynamic patterns in metabolic biomarkers and target proteins and activating both intrinsic and extrinsic pathways .
For example; Aloe excelsa, Artemisia annua
, Yucca schidigera, Azadirachta indica (Neem), Triticum aestivum, Beta vulgaris, Curcuma longa, Echinaceapurpure, Agele marmelos, Origanum vulgare, Saccharum officinarum, and Eclipta alba.
Artemisinin (also known as qinghao su) and its derivatives are a new class of antimalarials derived from the sweet wormwood plant Artemisia annua
. Initially developed in China in the 1970s, this class gained global attention in the 1990s.
aegypti, such as the essential oil of Tagetes minuta L (Lima, Chiaravalloti Neto, Macoris, Zuccari & Dibo, 2009) and the crude extract of Artemisia annua
Previous research confirmed that Artemisia annua
L., which also belongs to the genus Artemisia, also has quinic acid derivatives as the major constituents.
TABLE 1: Plant-derived natural products approved for therapeutic use Trade name/Year Generic name Plant species of introduction Indication Artemisinin Artemisia annua
Artemisinin-1987 Malaria treatment Capsaicin Capsicum annuum Qutenza-2010 Postherpetic neuralgia Galantamine Galanthus Razadyne-2001 Dementia caucasicus associated with ALZ Ingenol Euphorbia peplus Picato-2012 Actinic mebutate keratosis Paclitaxel Taxus brevifolia Taxol-1993 Cancer Abraxane-2005 chemotherapy Nanoxel-2007 Masoprocol Larrea tridentata Actinex-1992 Cancer chemotherapy Source: Atanasov et al.