artemisinin

(redirected from Artemisinins)
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ar·te·mis·i·nin

 (är′tə-mĭs′ĭ-nĭn)
n.
1. A compound, C15H22O5, that is obtained from a species of artemisia (Artemisia annua) and has antimalarial activity.
2. Any of several semisynthetic derivatives of this compound that are used to treat malaria, usually in combination with other drugs.

artemisinin

(ˌɑːtɪˈmɪzɪnɪn) pharmacol
n
a drug obtained from the plant genus Artemisia and used to treat malaria(as modifier)
Translations

artemisinin

n artemisinina
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References in periodicals archive ?
Artemisinins have been reported to be relatively safe, however there are concerns on some recently reported adverse effects.
Another Nigerian study showed that chloroquine was mostly used for treating severe malaria from 2000-2006 in children less than 5 years despite recommendation by the National Treatment Policy (2005) [10] to switch over to quinine and parenteral artemisinins.
The use of oral Artemisinin based monotherapies threatens the therapeutic life of ACTs by fostering the spread of resistance to artemisinins.
is some early evidence that resistance to artemisinins may also be emerging on
Artemisinins are a class of compounds that include artesunate, artemether, and artemisinin and have potent antimalarial activity.
"Artemisinins are essential weapons in our war against malaria," said Nick White, one of the scientists involved in the study.
In the current study, the Heidelberg scientists tested the effect of combination therapies with artemisinins and methylene blue on gametocytes in the blood.
In light of earlier results, the researchers are confident that the artemisinins are the greater contributors to the combinations' success.
In 1999, prominent infectious disease specialists penned an article in the prestigious British medical journal, The Lancet, calling for a rapid rollout of artemisinins in Africa.
Results: The mRNA expression of 20 genes represented by 59 different cDNA clones significantly correlated to the [log.sub.10] [IC.sub.50] values for the artemisinins, including genes encoding transferrin (TF), transferrin receptors 1 and 2 (TFRC, TFR2), cerulopasmin (CP), lactoferrin (LTF) and others.
Current perspectives on the mechanism of action of artemisinins. Int J Parasitol 2006; 35(14): 1427-41.