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Since carbofuron induced stress in rats is associated with depletion of ascorbic acid content, these findings support the hypothesis that ascorbic acid deficiency is involved in the pathogenesis of free radical induced oxidative stress in rats.
"The implications of these findings underscore the importance of obtaining the RDA for dietary vitamin C in order to decrease the prevalence of serum ascorbic acid deficiency in young Canadians and to potentially decrease the risk of long-term adverse health effects," the authors write.
Ascorbic acid deficiency is often present in many HD patients due to its removal during dialysis and lack of dietary intake (Ponka & Kuhlback, 1983).