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The process of self-digestion by a cell through the action of enzymes originating within the same cell.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(ɔːˈtɒfədʒɪ) or


the consumption of one's own tissue by biting oneself
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

autophagy, autophagia

Medicine. 1. the eating of one’s own body.
2. the nutrition of the body by its own tissues, as in dieting. — autophagous, adj.
See also: Food and Nutrition
-Ologies & -Isms. Copyright 2008 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Does LRBA interact physically with autophagy-related molecules such as LC3, ATG or Rab7?, By studying vesicular trafficking and autophagy, we found a possible connection mediated by Rab7, which is needed for the fusion between late endosomes and the autophagolysosome, which might suggest that LRBA is required for the fusion between these two organelles.
Autophagy, a catabolic mechanism, involves the degradation of damaged cellular and molecular components through the formation of a double membrane structure known as autophagosome, which fuses with the lysosome to form the autophagolysosome, surrounding the structures that will be degraded [2].
Lysosome is essential for the formation of autophagolysosome. To understand the role of zinc depletion in RPE autophagy, we measured the expression of Beclin-1 in RPE cells cultured under different conditions using Western blot.
In ECs [Figure 2]f, autophagolysosome was also found.{Figure 2}
Mitophagy is a specialized form of autophagy in which mitochondria are specifically targeted for degradation at the autophagolysosome [57].
The autophagosome, a double membrane structure containing engulfed cytoplasm and its organelle content, fuses with lysosome(s) to create an autophagolysosome within which the endocytosed contents can be degraded by lysosomal enzymes.
Autophagy, as a dynamic process, might be divided into few stages including (i) induction of the process, (ii) autophagosome formation, (iii) autophagolysosome formation, and (iv) delivery and degradation of the autophagic body.
Another regulator of the autophagolysosome formation is the PLEKHM1, (pleckstrin homology domain containing protein family member 1) which controls the fusion through binding to LC3 and HOPS (homotypic fusion and protein sorting) complex, as genetic loss of PLEKHM1 leads to an impaired autophagosome-lysosome fusion [117].
Isidoro, "Resveratrol-induced apoptosis depends on the lipid kinase activity of Vps34 and on the formation of autophagolysosomes," Carcinogenesis, vol.
Autophagy is also strongly induced by bacteria, viruses, and fungal organisms that ultimately are enclosed within autophagosomes and digested within the autophagolysosomes [7, 8].
Similar to LC3B, Lamp1 expression was increased in the cortices and hippocampi of APP/PS1 mice and exhibited a plaque-like distribution which is consistent with the previous studies which revealed strong immunoreactivity of Lamp1/2 in cells and in cell process surrounding plaques in AD brains [Figure 1]c.[20],[21] This may be due to the accumulation of lysosomes and autophagolysosomes in neurites or glial cells around amyloid plaques.
Moreover, a recent report described the ability of EGCG to increase autophagy through palmitate-induced lipid accumulation that likely involved autophagic flux and co-localization of lipid droplets and autophagolysosomes (Kim et al.