drap

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drap

(dræp)
n, vb
a Scot word for drop
References in periodicals archive ?
[beta]-secretase has two isoforms including p-Secretase Enzyme in AD I (BACEl) and P-Secretase Enzyme in AD 2 (BACE2).
Association studies using novel polymorphisms in BACE1 and BACE2. Neuroreport 2001;12(9):1799-1802.
Cadavez et al., "Inhibition of BACE2 counteracts hIAPP-induced insulin secretory defects in pancreatic beta-cells," FASEB Journal, vol.
In the nonamyloidogenic pathway, APP is cleaved by [upsilon]-secretase (PS1 and PS2) and [alpha]-secretase (ADAM10 and TACE); however APP processing by [upsilon]-secretase and [beta]-secretase (BACE1 and BACE2) shows features associated with AD pathogenesis [24].
Some well-known AD-related DEGs were dysregulated in our study, such as APP, CDK5R1, BACE2, PSENEN, GRIN2B, ADAM10, and TNFRSF1A.
BACE2 and ERG showed a maximum level of expression in the external and internal left globus pallidus (2.44/2.09 and 2.37/2.22) respectively.
The highly sensitive substrate used in the assay can detect as low as 0.8 ng/ml active IDE and has minimal cross reaction with Neprilysin, TACE, b-Secretase, ADAM10 and BACE2.
Beta-amyloid precursor protein cleavage enzyme 2 (BACE2) is a close homolog to BACE1 with 64% amino acid sequence similarity [3], and orthologs of both human BACE1 and BACE2 genes are present in marmoset, cattle, rabbit, guinea pig, rat, and mouse.
Based on NCBI database, the screened differentially expressed genes Apaf1, Bace2, and Plcb4 were enriched in the "Alzheimer's disease-reference pathway" (P < 0.01) (Figure 4) and meanwhile significantly downregulated in A[[beta].sub.25-35]-injured PC12 cells after ME intervention as compared with A[[beta].sub.25-35] group (P < 0.05) (Table 3).
Researchers found variants in two genes - HKDC1 and BACE2 - that were associated with measures of glucose and insulin levels of pregnant women but not associated with these measures in the rest of the population, including people with type 2 diabetes.
Stoffel and his team found the culprit: Bace2, an enzyme protein that, like Tmem27, also resides on the outer surface (known as the plasma membrane) of the beta cell.