While working with mice that spontaneously develop Type 1 diabetes, researchers found that by blocking BAFF
(a hormone that controls survival of B cells) prior to onset, none of the mice developed diabetes.
Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF
Researchers believe that BAFF
stimulates myeloma cells
Based on the wealth of new information regarding the treatment of SLE and BAFF
inhibition, we are fortunate to have had the opportunity to adjust our trial design," said Dr.
The wealth of new information released over the past year regarding the treatment of SLE and BAFF
inhibition provides an excellent opportunity to re-evaluate how we think about SLE, from optimal trial design to improving patient selection," said Dr.
Tabalumab binds and inhibits the activity of soluble and cell surface-bound BAFF
which then decreases the activity, proliferation, and survival of B cells.
Anthera's Phase 3 development product candidate, blisibimod, targets elevated levels of B-cell activating factor, or BAFF
, which has been associated with a variety of B-cell mediated autoimmune diseases, including systemic lupus erythematosus (SLE), or lupus, Immunoglobin A nephropathy, or IgAN, lupus nephritis, vasculitis, rheumatoid arthritis, idiopathic thrombocytopenia purpura, and others.
that targeting BAFF
with a molecule such as tabalumab may still
4) The BAFF
is produced by myeloid lineage cells, malignant B cells, activated T cells, and bone marrow stromal cells (5) and has three receptors that belong to the TNF receptor superfamily: the B cell maturation antigen (BCMA), the transmembrane activator, calcium-modulator and cyclophilin ligand interactor (TACI), and the BAFF
The new treatment facility shall be totally independent of the existing BAFF
In this latter regard, Mogabgab says that in the near future BAFF
will run a contest for film treatments on Lebanese culture, with winning entries receiving development and production assistance.
This is to maintain the status of BAFF
as a foreign invested joint venture.