In a series of patients with breast cancer receiving high-dose cyclophosphamide, cisplatin, and BCNU
followed by autologous HSCT, >30% decline in diffusing gas transfer was observed in 15-18 weeks following the chemotherapy (68).
Bortey et al., "A phase 3 trial of local chemotherapy with biodegradable carmustine (BCNU
) wafers (Gliadel wafers) in patients with primary malignant glioma," Neuro-Oncology, vol.
Mission[R] esiRNA against mouse KIF11, FLUC, and mouse GSR, L-methionine, and BCNU
were obtained from Sigma Aldrich.
The reported cooperative effects of MJ with other drugs are shown in Table 3: (1) BCNU
(carmustine), an alkylating nitrosourea agent with no cytotoxic effect on pancreatic carcinoma cell line MIA PaCa-2 in vitro combined with MJ showed enhanced cell death .
High-dose chemotherapy (BCNU
300 mg/[m.sup.2], etoposide 200 mg/[m.sup.2], Ara-C 200 mg/[m.sup.2], melphalan 140 mg/[m.sup.2]) was given and autologous stem cell transplantation (ASCT) was performed.
Colvin et al., "The intracerebral distribution of BCNU
delivered by surgically implanted biodegradable polymers," Journal of Neurosurgery, vol.
investigated the delivery of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU
) to glioblastomas in rats with induced tumours with the help of FUS.
Yang et al., "The effectiveness of a magnetic nanoparticle-based delivery system for BCNU
in the treatment of gliomas," Biomaterials, vol.
Burger et al., "A randomized comparison of intra-arterial versus intravenous BCNU
, with or without intravenous 5-fluorouracil, for newly diagnosed patients with malignant glioma," Journal of Neurosurgery, vol.
PB-100: a potent and selective inhibitor of human BCNU
resistant glioblastoma cell multiplication.