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In a series of patients with breast cancer receiving high-dose cyclophosphamide, cisplatin, and BCNU followed by autologous HSCT, >30% decline in diffusing gas transfer was observed in 15-18 weeks following the chemotherapy (68).
Increased oxidative stress created by adenoviral MnSOD or CuZnSOD plus BCNU (1,3-bis(2-chloroethyl)-1-nitrosourea) inhibits breast cancer cell growth.
Bortey et al., "A phase 3 trial of local chemotherapy with biodegradable carmustine (BCNU) wafers (Gliadel wafers) in patients with primary malignant glioma," Neuro-Oncology, vol.
Mission[R] esiRNA against mouse KIF11, FLUC, and mouse GSR, L-methionine, and BCNU were obtained from Sigma Aldrich.
The reported cooperative effects of MJ with other drugs are shown in Table 3: (1) BCNU (carmustine), an alkylating nitrosourea agent with no cytotoxic effect on pancreatic carcinoma cell line MIA PaCa-2 in vitro combined with MJ showed enhanced cell death .
High-dose chemotherapy (BCNU 300 mg/[m.sup.2], etoposide 200 mg/[m.sup.2], Ara-C 200 mg/[m.sup.2], melphalan 140 mg/[m.sup.2]) was given and autologous stem cell transplantation (ASCT) was performed.
Colvin et al., "The intracerebral distribution of BCNU delivered by surgically implanted biodegradable polymers," Journal of Neurosurgery, vol.
investigated the delivery of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) to glioblastomas in rats with induced tumours with the help of FUS.
Yang et al., "The effectiveness of a magnetic nanoparticle-based delivery system for BCNU in the treatment of gliomas," Biomaterials, vol.
Burger et al., "A randomized comparison of intra-arterial versus intravenous BCNU, with or without intravenous 5-fluorouracil, for newly diagnosed patients with malignant glioma," Journal of Neurosurgery, vol.
PB-100: a potent and selective inhibitor of human BCNU resistant glioblastoma cell multiplication.
El incluso sugiere el uso de quimioterapia intracavitaria con Wafers de BCNU (3.85% 1,3-bis-(2-chloroethyl)-1-nitrosourea) conocido comercialmente como Gliadel.
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- BCNU, Etoposide, Ara-C, Melphalan